依巴斯汀治疗过敏性鼻炎的临床疗效观察及其应用价值的评估

发布时间：2018-03-28 09:34

本文选题：过敏性鼻炎　切入点：变应性鼻炎　出处：《吉林大学》2011年硕士论文

【摘要】：过敏性鼻炎(allergic rhinitis,AR)又称变应性鼻炎,是鼻腔粘膜接触致敏原后发生的一种变态反应性疾病,具有打喷嚏、流清涕、鼻痒、鼻塞等症状,是耳鼻咽喉科常见疾病之一。目前过敏性鼻炎的发病率在一定范围内呈现出明显升高的趋势,尤其在一些大中城市中,其发病率不断升高。大量文献报道,过敏性鼻炎已经不仅仅是一个健康问题,它甚至涉及到更深层次的社会、经济危机。因此,对过敏性鼻炎的防治问题刻不容缓。目前抗组胺药物( H1受体拮抗剂)治疗过敏性鼻炎的疗效得到了学者的一致认可,同时临床上已有多种抗组胺药可供选择,但往往由于这类药物的副作用以及药物的耐药性大大限制了它的临床应用价值。因此,我们迫切需要发掘一种作用效果显著、副作用少的药物来解决患者的病痛。依巴斯汀(Ebastine)是一种第二代抗组胺药物,其治疗过敏性鼻炎的疗效已有相关报道,但在东北地区尚缺少系统研究。本次研究选取吉林大学第一附属医院门诊确诊为过敏性鼻炎患者59例,对应用依巴斯汀治疗前后其临床症状的评分进行统计学分析比较。同时以鼻腔局部应用糖皮质激素类药物作为对比参照。结果显示口服依巴斯汀或合并鼻腔局部糖皮质激素用药后自觉症状得到明显改善,有效率达到100%,未发现明显不良反应。因此针对东北地区过敏性鼻炎患者,依巴斯汀不失为治疗过敏性鼻炎的一种有效用药。目的:治疗过敏性鼻炎的方法众多,但许多由于其局限性而影响了其临床应用价值。依巴斯汀为治疗过敏性鼻炎的一种新药。本研究目的在于通过对就诊于吉林大学第一附属医院耳鼻喉科门诊确诊为过敏性鼻炎患者给予依巴斯汀治疗后,对依巴斯汀的临床疗效进行观察与分析,为今后治疗过敏性鼻炎提供新的选择。方法:根据入选标准收集吉林大学第一附属医院门诊确诊为过敏性鼻炎患者59例,对应用依巴斯汀治疗前后其临床症状的评分进行统计学分析比较。同时以鼻腔局部应用糖皮质激素类药物作为对比参照。结果:在临床观察中,患有过敏性鼻炎的患者口服依巴斯汀(开思亭)后,其临床症状评分在用药前后有明显差异,表明依巴斯汀治疗过敏性鼻炎效果显著,有效率达到100%,同时未发现明显不良反应,用药安全。在比较依巴斯汀治疗过敏性鼻炎是否合并鼻腔局部糖皮质激素用药时,两比较组没有显著差异。结论: 1、通过对依巴斯汀治疗过敏性鼻炎的临床疗效观察,其治疗过敏性鼻炎效果显著。 2、依巴斯汀被用于治疗过敏性鼻炎过程中未发现明显不良反应,因此其在用药安全性方面可以放心使用。 3、通过对比依巴斯汀治疗过敏性鼻炎时鼻腔是否合并应用糖皮质激素类喷雾剂的临床效果,未发现明显统计学差异,故依巴斯汀在需要快速解决过敏性鼻炎症状时可以单独用药。
[Abstract]:Allergic rhinitis ( AR ) is also known as allergic rhinitis . It is a kind of allergic rhinitis after nasal mucosa contact sensitization . It is a common disease in the throat department of the ear .

Objective : To study the clinical application value of Ebastine in the treatment of allergic rhinitis . The aim of this study is to observe and analyze the clinical curative effect of Ebastine after the treatment of allergic rhinitis in the first affiliated hospital of Jilin University . It provides a new choice for the treatment of allergic rhinitis in the future .

Methods : 59 cases of allergic rhinitis were collected from the outpatient department of the First Affiliated Hospital of Jilin University according to the inclusion criteria , and the scores of clinical symptoms before and after the treatment of Ebastine were analyzed and compared .

Results : In clinical observation , the clinical symptom scores of patients with allergic rhinitis were significantly different before and after administration , indicating that Ebastine was effective in the treatment of allergic rhinitis , the effective rate reached 100 % , and no obvious adverse reaction was found .

Conclusion :

1 . According to the clinical curative effect observation of Ebastine in treating allergic rhinitis , the method has obvious effect on treating allergic rhinitis .

2 . Ebastine is used in the treatment of allergic rhinitis , no obvious adverse reaction is found , so it can be used for the safety of medication .

3 . By comparing the clinical effects of ebastine in the treatment of allergic rhinitis , no significant statistical difference was found , so Ebastine could be used alone in the rapid resolution of allergic rhinitis symptoms .

【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R765.21

【共引文献】