基质金属蛋白酶-9基因多态性与喉癌易感性及预后的研究

发布时间：2018-04-01 06:16

本文选题：喉肿瘤　切入点：基质金属蛋白酶类　出处：《临床耳鼻咽喉头颈外科杂志》2014年12期

【摘要】：目的:探讨MMP-9基因多态性与喉癌易感性及临床病理特征和预后的关系。方法:应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测142例喉癌患者和200例健康对照者MMP-9-1562C/T单核苷酸多态性位点的基因型。结果:携带MMP-9-1562CC基因型者患喉癌的风险高于携带MMP-9-1562CT/TT基因型者(P0.05,95%CI=1.02~2.77);MMP-9-1562C/T基因多态性与喉癌患者年龄、性别、T分期、临床分期及淋巴结转移无相关性;Kaplan-Meier生存分析结果显示,MMP-9-1562CC基因型患者的生存率低于TT和CT基因型患者(P0.01);COX回归分析显示,携带MMP-9-1562CC基因型的患者预后不良。结论:MMP-9-1562C/T基因多态性与喉癌的发病风险相关;MMP-9-1562C/T基因多态性可能是影响预后的独立危险因素。
[Abstract]:Objective: to investigate the relationship between MMP-9 gene polymorphism and susceptibility, clinicopathological features and prognosis of laryngeal carcinoma.Methods: polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the genotypes of MMP-9-1562C/T single nucleotide polymorphisms in 142 patients with laryngeal carcinoma and 200 healthy controls.Results: the risk of laryngeal cancer in patients with MMP-9-1562CC genotype was higher than that in patients with MMP-9-1562CT/TT genotype (P 0.05 / 95). The polymorphism of MMP-9-1562C / T gene in patients with MMP-9-1562CT/TT genotype was significantly higher than that in patients with MMP-9-1562CT/TT genotype.Kaplan-Meier survival analysis showed that the survival rate of patients with MMP-9-1562CC genotype was lower than that of patients with TT and CT genotypes (P 0.01). The prognosis of patients with MMP-9-1562CC genotype was poor.Conclusion the ratio of MMP-9-1562C / T polymorphism is associated with the risk of laryngeal cancer. The MMP-9-1562C / T polymorphism may be an independent risk factor for prognosis.
【作者单位】：南京大学医学院附属鼓楼医院耳鼻咽喉头颈外科;无锡市第一人民医院耳鼻咽喉头颈外科;
【基金】：南京市医学科技发展项目基金资助(No:YKK11099)
【分类号】：R739.65

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