益肾活血通窍汤合西药治疗肾精亏损型感音神经性耳鸣的临床观察

发布时间：2018-04-04 16:53

本文选题：益肾活血通窍汤　切入点：肾精亏损型　出处：《福建中医药大学》2011年硕士论文

【摘要】：目的：通过对益肾活血通窍汤合西药(西比灵、谷维素)治疗肾精亏损型感音神经性耳鸣的临床疗效进行观察,研究益肾活血通窍汤的临床价值,为中西医结合治疗肾精亏损型感音神经性耳鸣提供临床思路。方法：将肾精亏损型感音神经性耳鸣的患者58例,随机分为治疗组、对照组,其中治疗组29例37耳,对照组29例38耳。治疗组口服中药益肾活血通窍汤合西药(西比灵、谷维素)治疗,对照组单纯口服西药(西比灵、谷维素)治疗,15天为一疗程,两组均连续用药30天,并对患者进行临床随访1个月,按照制定的疗效评定标准,分别观察两组疗效。结果： 1.两个疗程结束后,并对患者进行临床随访1个月,治疗组和对照组治疗前后耳鸣程度症状分级量化积分进行组间比较,差异有统计学意义；治疗组总有效率82.99%,对照组总有效率54.78%,经统计学观察两组患者疗效,有统计学意义(P0.05)； 2.治疗组耳鸣疗效与听力障碍存在及其轻重程度有明显关系(P0.05)； 3.治疗组耳鸣疗效与病程有关,病程3月、病程4月-1年、病程1年总有效率分别为：95.24%、75.0%、50.0%，，有统计学意义(P0.05)。结论： 1.治疗组和对照组治疗肾精亏损型感音神经性耳鸣均具有一定的疗效,治疗组疗效明显优于对照组。 2.治疗组耳鸣疗效与听力障碍存在及其轻重程度有明显关系。 3.治疗组耳鸣疗效与病程有关,且疗程越短疗效越好。 4.经验方益肾活血通窍汤以补肾填精,活血通窍为主要功用,是治疗感音神经性耳鸣肾精亏损证的有效方剂,与西比灵、谷维素组相比,改善耳鸣及其伴随症状效果更明显,因而具有一定的优势。 5.肾精亏损型感音神经性耳鸣患者与年龄关系密切,且以老年人发病最为多见,与性别无明显关系。 6.治疗组在治疗前、后均进行血、尿常规,肝、肾功能,常规心电图等安全性检测,均未发现不良反应,表明益肾活血通窍汤合西药(西比灵、谷维素)治疗肾精亏损型感音神经性耳鸣是中西医结合治疗耳鸣安全可靠的方法,值得临床推广应用。
[Abstract]:Objective: to study the clinical value of Yishen Huoxue Tongqiao decoction (Yishen Huoxue Tongqiao decoction) combined with western medicine (sibeiling, oryzanol) in the treatment of sensorineural tinnitus with deficiency of kidney essence, and to study the clinical value of Yishen Huoxue Tongqiao decoction.To provide clinical thinking for the treatment of sensorineural tinnitus with deficiency of kidney essence by combination of traditional Chinese and western medicine.Methods: 58 cases of sensorineural tinnitus with deficiency of kidney essence were randomly divided into two groups: treatment group (n = 29), control group (n = 37) and control group (n = 29).The treatment group was treated with traditional Chinese medicine Yishen Huoxue Tongqiao decoction and western medicine (sibeiling, oryzanol), while the control group was treated with oral western medicine (sibelium, oryzanol) for 15 days as a course of treatment. The two groups were treated continuously for 30 days.The patients were followed up for 1 month.Results:1.After two courses of treatment, the patients were followed up for 1 month. The scores of tinnitus degree were compared between the treatment group and the control group before and after treatment, the difference was statistically significant.The total effective rate was 82.99 in the treatment group and 54.78 in the control group.2.The curative effect of tinnitus in the treatment group was significantly related to the presence and severity of hearing impairment.3.The curative effect of tinnitus in the treatment group was related to the course of disease. The total effective rates of the course of disease were 3 months, 4 months to 1 year, and the total effective rate of one year was 50.0, respectively.Conclusion:1.Both the treatment group and the control group were effective in the treatment of sensorineural tinnitus with deficiency of kidney essence, and the curative effect of the treatment group was significantly better than that of the control group.2.The curative effect of tinnitus in the treatment group was significantly related to the existence and severity of hearing impairment.3.The curative effect of tinnitus in the treatment group was related to the course of disease, and the shorter the course of treatment, the better the curative effect.4.Experience prescription Yishen Huoxue Tongqiao decoction, which is mainly used to invigorate kidney, activate blood circulation and clear orifices, is an effective prescription for the treatment of deficiency syndrome of sensorineural tinnitus and kidney essence. Compared with sibeiling and oryzol groups, the effect of improving tinnitus and its associated symptoms is more obvious.As a result, there are certain advantages.5.The patients with sensorineural tinnitus of deficiency type of kidney essence were closely related to age, and the elderly were the most common, but had no obvious relationship with sex.6.Before and after treatment, blood, urine routine, liver, kidney function, routine electrocardiogram and other safety tests were performed in the treatment group. No adverse reactions were found, indicating that Yishen Huoxue Tongqiao decoction combined with western medicine (Sibiline),Oryzanol) is a safe and reliable method for the treatment of tinnitus with deficiency of kidney essence.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R764.45

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