鼠神经生长因子治疗突发性聋的临床疗效研究

发布时间：2018-04-12 19:14

本文选题：鼠神经生长因子 + 突发性聋　；参考：《临床耳鼻咽喉头颈外科杂志》2014年10期

【摘要】：目的:研究鼠神经生长因子(NGF)辅助治疗突发性聋的临床疗效。方法:回顾性分析115例突发性聋患者,对照组采取常规治疗,采用改善微循环与激素冲击治疗,同时辅予能量合剂、口服甲钴胺营养神经治疗;NGF组在常规治疗的基础上辅予NGF肌注治疗;疗程均为14d,比较2组总有效率。根据影响疗效的因素如年龄、病程以及治疗前PTA水平分成亚组进一步进行分析,比较各亚组的总有效率。结果:①NGF组总有效率显著高于对照组;②不论年龄大小,NGF组的疗效均显著高于对照组;③初诊时间在7d以内的、治疗前PTA≤60dBHL的患者中,NGF组的有效率均显著高于对照组,而初诊时间为7d以上的、治疗前PTA60dBHL的患者采用NGF治疗疗效并不优于传统治疗方法。结论:NGF可显著提高病程较短、治疗前PTA较低的突发性聋患者的显效率。对于这一部份人群可积极推广NGF的辅助治疗。对于病程较长且治疗前PTA较高的患者则不主张推广使用NGF的辅助治疗,而NGF治疗的选择不应考虑年龄的因素。
[Abstract]:Objective: To study the rat nerve growth factor (NGF) clinical effects in the treatment of sudden deafness. Methods: a retrospective analysis of 115 cases of sudden deafness patients, the control group were given routine therapy, and corticosteroid therapy to improve microcirculation, while giving energy mixture, oral Mecobalamin treatment; group NGF received intramuscular injection of NGF. On the basis of routine treatment; the course of treatment was 14d, compared with 2 groups of the total efficiency. According to the effects of factors such as age, disease duration and PTA level before treatment were further divided into subgroups analysis, each subgroup were compared with the total efficiency. Results: the total effective rate of group NGF was significantly higher than the control group; the matter the age, the efficacy of the NGF group were significantly higher than the control group; the first time within 7d, PTA before treatment than 60dBHL patients, the effective rate of NGF group were significantly higher than control group, and the first time was more than 7d, PTA60dBHL before the treatment The curative effect of NGF patients is not superior to the traditional methods of treatment. Conclusion: NGF can significantly improve the short duration, sudden deafness patients before treatment PTA significant efficiency lower. This part of the crowd for the adjuvant treatment of active promotion of NGF. For longer duration and higher before treatment PTA patients do not advocate auxiliary the use of NGF treatment, and the treatment of choice for NGF should not consider the age factor.

【作者单位】：南京医科大学附属无锡市第二人民医院耳鼻咽喉科;
【分类号】：R764.43

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