白内障患者房水、血清及泪液中氧化应激指标和NO表达水平的变化

发布时间：2018-04-12 22:18

本文选题：白内障 + 氧化应激　；参考：《眼科新进展》2015年05期

【摘要】：目的观察白内障患者血清、房水及泪液中氧化应激指标和一氧化氮(nitric oxide,NO)的变化情况,并探讨其与白内障的相关性。方法选取2013年5月至2014年6月期间来我院就诊的白内障患者132例为观察组,选择同期健康志愿者132位作为对照组,比较两组房水、血清和泪液中丙二醛(methane dicarboxylic aldehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)、过氧化脂质(lipid peroxidation,LPO)、总抗氧化能力(total antioxidant capacity,TAC)及NO表达水平。并比较不同年龄组血清中各氧化应激指标及NO的表达差异。结果观察组房水、血清及泪液中MDA、LPO及NO表达水平均明显高于对照组,SOD及TAC均低于对照组,差异均有统计学意义(均为P0.05);随着白内障患者年龄的增长,观察组房水中SOD及TAC表达水平明显下降,而MDA、NO及LPO表达水平明显升高,两组间差异均有统计学意义(均为P0.05)。结论白内障患者房水、泪液及血清中氧化应激因子及NO表达水平异常,导致眼内抗氧化系统改变,且与年龄存在相关性。
[Abstract]:Objective to observe the changes of oxidative stress index and nitric oxide nitric oxide (no) in serum, aqueous humor and tear of cataract patients, and to explore its correlation with cataract.Methods 132 cataract patients from May 2013 to June 2014 were selected as observation group and 132 healthy volunteers as control group.In serum and tear, malondialdehyde (MDA) methane dicarboxylic aldehydede (MDAA), superoxide dismutase (SOD), lipid peroxidation (LPO), total antioxidant capacity (TOC) and no expression were detected.The serum oxidative stress index and no expression in different age groups were compared.Results the levels of MDA-LPO and no in aqueous humor, serum and tear in the observation group were significantly higher than those in the control group (P 0.05).The expression of SOD and TAC in aqueous humor of the observation group was significantly decreased, while the expression of no and LPO in the aqueous humor of the observation group was significantly higher than that in the control group (P 0.05).Conclusion the abnormal levels of oxidative stress factor and no in aqueous humor, tear and serum of cataract patients lead to the change of antioxidation system in the eyes, and there is a correlation with age.
【作者单位】：重庆市渝北区人民医院眼科;
【分类号】：R776.1

【参考文献】