三乙醇胺乳膏防治鼻咽癌放射性口腔粘膜炎的临床观察

发布时间：2018-04-13 17:02

本文选题：三乙醇胺乳膏 + 鼻咽癌　；参考：《广西医科大学》2010年硕士论文

【摘要】： 背景和目的:急性放射性口腔粘膜炎是鼻咽癌(NPC)放射治疗过程中最常见的副反应。本研究旨在探讨鼻咽癌放射性口腔粘膜炎的有效防治措施。方法:选取2008年3月～2009年12月在广西医科大学第三附属医院肿瘤科就诊的鼻咽癌患者58例,全部病例均已经病理证实。将58例鼻咽癌患者采用抽签法随机分为三乙醇胺组(n = 30)及对照组(n = 28),三乙醇胺组于放疗第一天开始,每次放疗结束后用30%三乙醇胺乳膏混合液(10ml生理盐水+3克三乙醇胺乳膏,自配)含漱,含漱液在口腔内保持10～15分钟,早晚各含漱一次,至放疗结束。放疗中患者出现II级及以上口腔粘膜炎时予常规处理。对照组只用生理盐水含漱,当患者出现II级及以上口腔粘膜炎时予三乙醇胺组同样处理。结果:1.三乙醇胺组和对照组患者的I级粘膜炎发生率分别为46.7%和3.60%,III级粘膜炎发生率分别为16.7%和42.8%,其差异有统计学意义(P 0.05);2.在照射剂量达20Gy及30Gy时,三乙醇胺组口腔粘膜炎发生率分别为33.3%(10例)和63.4%(19例),而对照组分别为78.5%(22例)和21.5%(6例),其差异均有统计学意义(P 0.05); 3.两组出现放射性口腔粘膜炎的时间:三乙醇胺组12～27天,中位18天,对照组5～22天,中位11天,三乙醇胺组明显晚于对照组。4.III级粘膜炎平均持续时间分别为8.2天和11.4天,差异有统计学意义(P 0.05)。结论:三乙醇胺乳膏混合液含漱对防治放射性口腔粘膜炎有较好的效果,明显推迟口腔粘膜反应出现时间,缩短粘膜修复时间,粘膜反应程度多为Ⅰ级,其取材方便,无毒副作用,值得临床推广应用。
[Abstract]:Background and objective: acute radiation oral mucositis is the most common side effect during radiotherapy for nasopharyngeal carcinoma (NPC).The purpose of this study was to investigate the effective prevention and treatment of nasopharyngeal carcinoma (NPC) radiation oral mucositis.Methods: from March 2008 to December 2009, 58 patients with nasopharyngeal carcinoma were selected from Department of Oncology, third affiliated Hospital of Guangxi Medical University.58 patients with nasopharyngeal carcinoma were randomly divided into triethanolamine group (n = 30) and control group (n = 28).After each radiotherapy, the mixture of 30% triethanolamine cream and 10 ml normal saline 3 g triethanolamine cream was used to gargle. The gargle was kept in the mouth for 1015 minutes, once in the morning and evening, until the end of radiotherapy.Patients with grade II or above oral mucositis during radiotherapy were treated routinely.The control group was gargled only with normal saline, and the triethanolamine group was treated with triethanolamine when the patients developed grade II or above oral mucositis.The result is 1: 1.The incidence of grade I mucositis in triethanolamine group and control group was 46.7% and 3.60%, respectively. The incidence of grade III mucositis was 16.7% and 42.8%, respectively. The difference was statistically significant (P 0.05).The incidence of oral mucositis in triethanolamine group was 33.3% (10 cases) and 63.4% (19 cases), while that in control group was 78.5% (22 cases) and 21.5% (6 cases).The mean duration of oral mucositis in the triethanolamine group was 8.2 days later than that in the control group (8.2 days and 11.4 days, respectively), with a median of 18 days, 522 days in the control group and 11 days in the control group, and the mean duration of oral mucositis in the triethanolamine group was 8.2 days and 11.4 days, respectively.The difference was statistically significant (P 0.05).Conclusion: the mixture of triethanolamine cream gargle has a better effect on prevention and treatment of radioactive oral mucositis. It can obviously delay the time of oral mucosal reaction and shorten the time of mucosal repair.No toxic side effects, worthy of clinical application.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R739.63

【引证文献】