连接子蛋白43、上皮型黏附素和基质金属蛋白酶9在老年眼睑基底细胞癌患者癌组织中表达的关系

发布时间：2018-04-14 05:39

本文选题：眼睑基底细胞癌 + 连接子蛋白(CX)　；参考：《中国老年学杂志》2014年12期

【摘要】：目的检测老年眼睑基底细胞癌患者癌组织中连接子蛋白(CX)43、上皮型黏附素(E-cadherin)和基质金属蛋白酶(MMP)-9的表达特征,关注三者的关系及临床意义。方法 98例老年眼睑基底细胞癌患者术后蜡块组织及临床资料作为观察组,以70例老年基底细胞乳头状瘤患者作为对照组,应用免疫组化检测CX43、E-cadherin和MMP-9的表达,关注CX43、E-cadherin和MMP-9的关系及在不同临床特征中的表达差别。结果观察组CX43和E-cadherin表达阳性率明显低于对照组,观察组MMP-9表达阳性率明显高于对照组,观察组CX43、E-cadherin和MMP-9表达与肿瘤最大径、临床分期及Ki67表达密切相关。观察组CX43和E-cadherin、CX43和MMP-9表达具有正相关性。结论老年眼睑基底细胞癌患者癌组织中CX43和E-cadherin低表达、MMP-9高表达可以有效促进肿瘤发生和进展。CX43在抑制肿瘤进展中可能通过调节细胞间的连接、黏附和细胞外基质的作用发挥其功能。
[Abstract]:Objective to investigate the expression of CXP43, E-cadherin (E-cadherin) and MMP-9 in the carcinoma of eyelid basal cell carcinoma (BCC) in elderly patients, and to investigate the relationship between them and their clinical significance.Methods the expression of CX43 E-cadherin and MMP-9 was detected by immunohistochemistry in 98 elderly patients with basal cell carcinoma of eyelid and 70 elderly patients with basal cell papilloma as control group.Attention was paid to the relationship between CX43 E-cadherin and MMP-9 and the difference of expression in different clinical features.Results the positive rate of CX43 and E-cadherin expression in the observation group was significantly lower than that in the control group, and the positive rate of MMP-9 expression in the observation group was significantly higher than that in the control group. The expression of CX43 E-cadherin and MMP-9 was closely related to the maximum diameter of tumor, clinical stage and Ki67 expression in the observation group.There was a positive correlation between the expression of CX43 and CX43 and MMP-9 in the observation group.Conclusion the low expression of MMP-9 and the low expression of MMP-9 in the carcinoma of eyelid basal cell carcinoma can promote the development and progression of the tumor. CX43 may regulate the intercellular connection in the inhibition of tumor progression.Adhesion and extracellular matrix function.
【作者单位】：青海大学附属医院眼科;
【分类号】：R739.71

【参考文献】