光学相干断层扫描仪在慢性原发性闭角型青光眼早期诊断中的应用

发布时间：2018-04-15 03:12

本文选题：慢性原发性闭角型青光眼 + 光学相干断层扫描仪　；参考：《中国医科大学》2010年硕士论文

【摘要】： 目的探讨光学相干断层扫描仪(optical coherence tomography,OCT)检测视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度在慢性原发性闭角型青光眼(Chronic primary angle-closure glaucoma, CPACG)早期诊断中应用。方法正常对照组19例(28眼),青光眼患者30例(39眼)并分为早期、中晚期2组。采用OCT进行盘周RNFL厚度的测量,比较正常对照组与早期CPACG患者RNFL厚度的差异,并通过计算RNFL各厚度参数在ROC曲线下面积评价OCT在青光眼早期诊断中的应用。结果早期CPACG患者平均和颞侧RNFL厚度及视盘周围1点、7点、9点、10点、11点钟RNFL厚度较正常对照组明显变薄；除3点钟外,早期及中晚期CPACG的RNFL厚度较正常对照组明显变薄；9点、10点及颞侧RNFL在ROC曲线下面积最大,分别为0.819、0.816、0.811。结论早期CPACG的RNFL已变薄,通过计算早期CPACG厚度参数在ROC曲线下面积可以为青光眼的早期诊断提供了一项有用指标。
[Abstract]:PurposeObjective to investigate the application of optical coherence tomography (coherence) in the early diagnosis of chronic primary angle closure glaucoma (CPACG) by using optical coherence tomography (coherence) to detect the thickness of retinal nerve fiber layer (RNFL) in chronic primary angle-closure glaucoma.MethodThe normal control group consisted of 19 patients (28 eyes) and 30 glaucoma patients (39 eyes).The peridisc RNFL thickness was measured by OCT, and the difference of RNFL thickness between the normal control group and the early CPACG patients was compared, and the application of OCT in the early diagnosis of glaucoma was evaluated by calculating the thickness parameters of RNFL under the ROC curve.ResultThe mean and temporal RNFL thickness in early CPACG patients and the RNFL thickness at 10 and 11 o'clock around the optic disc were significantly thinner than those in the normal control group, except at 3 o'clock.The RNFL thickness of early and middle stage CPACG was significantly thinner than that of normal control group at 9 points and 10 points, and the area of temporal RNFL was the largest under the ROC curve, which was 0.819 ~ 0.816 ~ 0.811, respectively.ConclusionThe RNFL of early CPACG has been thinned. Calculating the area under ROC curve of early CPACG thickness parameter can provide a useful index for the early diagnosis of glaucoma.
【学位授予单位】：中国医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R775

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