甲基强的松龙联合复方樟柳碱治疗急性视神经炎的临床观察

发布时间：2018-04-17 02:23

本文选题：视神经炎 + 复方樟柳碱　；参考：《广西医科大学》2014年硕士论文

【摘要】：目的:探讨大剂量甲基强的松龙联合复方樟柳碱治疗视神经炎的临床疗效方法:对广西医科大学一附院眼科2012年1月至2013年12月收治的急性视神经炎患者的病案资料进行回顾性分析。临床确诊为视神经炎的51例患者69眼纳入研究，其中，视神经乳头炎16例，球后视神经炎35例，将患者分为治疗组和对照组，分别为25例34只眼和26例35只眼，治疗组给予维生素B1，B1210mg口服,3次/日,甲基强的松龙500mg溶于500ml5%葡萄糖氯化钠溶液中静脉滴注，每日一次，连用6日后，减为240mg/d，连用3天后改醋酸泼尼松龙片60mg晨起顿服，每周减2片，减至30mg时小剂量递减维持，同时注意补钾护胃补钙。并以复方樟柳碱注射液2ml患侧颞浅动脉旁皮下注射，每日一次，对照组除不用复方樟柳碱注射液外，其余处理与治疗组相同。对比分析两组治疗后的疗效差异。结果:治疗组治愈15眼，显效14眼，有效4眼，无效1眼，总有效率97%；对照组治愈10眼，显效11眼，有效10眼，无效4眼，总有效率88.5%。两组的总有效率比较有统计学意义（P0.05) 结论:复方樟柳碱颞浅动脉旁皮下注射治疗早期视神经炎，可有效改善视神经及附近的血液循环，改善血供，促进组织缺血,缺氧在短时间内得到恢复，从而改善患者视力。且临床运用安全有效，，价格低廉，值得推广。
[Abstract]:Objective: to investigate the clinical effect of high-dose methylprednisolone combined with compound anisodine in the treatment of optic neuritis.Methods: the medical records of patients with acute optic neuritis admitted from January 2012 to December 2013 in the affiliated Hospital of Guangxi Medical University were retrospectively analyzed.Sixty-nine eyes of 51 patients with optic neuritis were included in the study. Among them, there were 16 cases of optic papilltis and 35 cases of retrobulbar optic neuritis. The patients were divided into treatment group and control group, 25 cases, 34 eyes and 26 cases, 35 eyes, respectively.In the treatment group, vitamin B1 B1210mg was given orally three times a day. Methylprednisolone 500mg was given intravenously in 500ml 5% glucose sodium chloride solution, once a day for 6 days, reduced to 240 mg / d. After 3 days of treatment, prednisolone acetate tablet 60mg was taken in the morning.Decrease 2 tablets a week, reduce to 30mg, small dose decrease and maintain, at the same time, pay attention to potassium to protect stomach to supplement calcium.Compound anisodine injection (2ml) was injected subcutaneously to the superficial temporal artery of the affected side once a day. The control group was treated the same as the treatment group except for the compound anisodine injection.The difference of curative effect between the two groups after treatment was compared and analyzed.Results: in the treatment group, 15 eyes were cured, 14 eyes were effective, 4 eyes were effective, 1 eye was ineffective, the total effective rate was 97%, while in the control group, 10 eyes were cured, 11 eyes were markedly effective, 10 eyes were effective, 4 eyes were ineffective, and the total effective rate was 88.5.The total effective rate of the two groups was significantly higher than that of the control group (P0.05).Conclusion: the treatment of early optic neuritis by subcutaneous injection of compound anisodine along the superficial temporal artery can effectively improve the blood circulation of the optic nerve and its vicinity, improve blood supply, promote tissue ischemia, and restore anoxia in a short time, thus improving the visual acuity of the patients.And the clinical application is safe and effective, the price is low, it is worth popularizing.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R774.61

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