外侧丘系腹核在声信号加工和听觉上行传导中的作用

发布时间：2018-04-18 12:14

本文选题：外侧丘系腹核 + 声信号加工　；参考：《生理学报》2014年03期

【摘要】：外侧丘系腹核(ventral nucleus of the lateral lemniscus,VNLL)是中枢听觉通路中连接耳蜗核等低位脑干和中脑下丘(inferior colliculus,IC)的重要核团,其神经元能够对声信号的不同参数进行检测与加工,进而形成多样的声反应特性。VNLL神经元对频率反应的调谐曲线有多种类型,但其锐化程度一般较低,对频率的分析亦不够精确;有关强度调谐的放电率函数分为两种类型:单调型与非单调型,它们对强度的加工和编码往往受到发放模式的影响;不同发放模式的VNLL神经元对时程的编码能力不同,其中起始型具有精确的时间特性,适合编码声刺激的起始时间信息,对蝙蝠的回声定位非常重要。VNLL接受来自低位核团的输入,并发出上行的抑制性投射至IC,在IC神经元的声信息检测过程中发挥重要作用。近来研究认为VNLL快速的抑制性投射延迟IC神经元的首次发放潜伏期,VNLL延迟的抑制性投射介导IC神经元的发放模式,但VNLL抑制性输入如何在IC进行整合,并增强IC神经元检测声信号能力的机制并不清楚,且缺乏VNLL对IC进行实时调控作用的直接证据。这些问题的研究有助于进一步认识上行输入在声信号加工过程中的作用,同时也是本实验室今后的研究重点。本文结合本实验室相关研究,围绕VNLL对听觉信号的加工和上行传导进行综述。
[Abstract]:Ventral nucleus of the lateral lemniscus VNLL is an important nucleus in the central auditory pathway that connects the low brainstem of the cochlear nucleus and the inferior colliculus of the midbrain. The neurons of the ventral nucleus of the lateral colliculus can detect and process the different parameters of the acoustic signal.The tuning curve of VNLL neurons to frequency response has many types, but its sharpening degree is generally low, and the frequency analysis is not accurate enough.The discharge rate function of intensity tuning can be divided into two types: monotonic type and non-monotone type, whose processing and coding of intensity are often affected by the firing mode, and the ability of VNLL neurons to encode time course is different.Among them, the initiation type has accurate time characteristics, which is suitable for encoding the initial time information of acoustic stimulation. It is very important for the echolocation of bats. VNLL receives input from low nuclei.The inhibitory projection to ICs plays an important role in the detection of acoustic information of IC neurons.Recent studies suggest that the first release latency of VNLL fast inhibitory projective delayed IC neurons mediates the release pattern of IC neurons, but how VNLL inhibitory input integrates in IC.The mechanism of enhancing the ability of IC neurons to detect acoustic signals is not clear, and there is no direct evidence that VNLL can regulate IC in real time.The study of these problems is helpful to further understand the role of uplink input in the process of acoustic signal processing, and is also the focus of our laboratory in the future.In this paper, we review the processing and uplink of auditory signals by VNLL.
【作者单位】：华中师范大学生命科学学院遗传调控与整合生物学湖北省重点实验室;
【基金】：supported by grants from the National Natural Science Foundation of China(No.31000493) Independent Scientific Research Project Fund for Youth Doctors from Central China Normal University(No.11A01025) Foundation of Hubei Key Laboratory of Genetic Regulation and Integrative Biology,China
【分类号】：R764

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