放疗对鼻咽癌患者唾液中钙、磷含量影响的研究

发布时间：2018-04-22 16:54

  本文选题：鼻咽癌 + 放疗　； 参考：《中南大学》2011年硕士论文

【摘要】：目的： 探讨鼻咽癌患者放疗后龋活性变化。定量分析鼻咽癌患者放疗前后唾液中的钙、磷含量及其变化,并以健康志愿者为对照,探讨放疗对鼻咽癌患者唾液中钙、磷含量的影响,为放射龋的预防和病因研究提供理论依据。 方法： 鼻咽癌患者28例和健康志愿者20例。刃天青纸片法检测鼻咽癌患者放疗前、放疗70Gy后的龋活性,火焰原子吸收光谱法和钼锑抗分光光度法测定鼻咽癌患者放疗前、放疗70Gy后及健康志愿者非刺激性唾液中的钙、磷含量。 结果： ①刃天青纸片法显示鼻咽癌患者放疗70Gy后龋活性增加(P0.01)。 ②鼻咽癌患者放疗前唾液中钙含量为63.19mg/l,放疗70Gy后唾液中钙含量为33.38mg/l。经统计分析,放疗前、放疗70Gy后唾液中钙含量的差异有统计学意义(P0.01)。鼻咽癌患者放疗前唾液中磷含量为132.96mg/l,放疗70Gy后唾液中磷含量为49.18mg/l,经统计分析,放疗前、放疗70Gy后唾液中磷含量的差异有统计学意义(P0.01)。男性、女性鼻咽癌患者放疗前、放疗70Gy后唾液中钙、磷含量的差异无统计学意义(P0.05)。男性、女性鼻咽癌患者放疗前、放疗70Gy后唾液中钙、磷含量差值的差异无统计学意义(P0.05)。Ⅲ期、Ⅳa期鼻咽癌患者放疗前、放疗70Gy后唾液中钙、磷含量的差异无统计学意义(P0.05)。Ⅲ期、Ⅳa期鼻咽癌患者放疗前、放疗70Gy后唾液中钙、磷含量差值的差异无统计学意义(P0.05)。 结论： ①放疗70Gy后鼻咽癌患者的龋活性增加。 ②放疗70Gy后唾液中钙、磷含量减少。鼻咽癌患者放疗前、放疗70Gy后唾液中钙、磷含量的变化与性别和临床分期无明显关系。
[Abstract]:Objective: To investigate the changes of caries activity in patients with nasopharyngeal carcinoma after radiotherapy. The contents and changes of calcium and phosphorus in saliva of patients with nasopharyngeal carcinoma before and after radiotherapy were analyzed quantitatively, and the effects of radiotherapy on the contents of calcium and phosphorus in saliva of patients with nasopharyngeal carcinoma were studied with healthy volunteers as control. To provide theoretical basis for the prevention and etiology of radiation caries. Methods: There were 28 patients with nasopharyngeal carcinoma and 20 healthy volunteers. The caries activity of nasopharyngeal carcinoma (NPC) patients before and after radiotherapy (70Gy) was detected by edge azure disk method. The calcium in nonirritated saliva was measured by flame atomic absorption spectrometry (FAS) and molybdenum antimony antimony antimony spectrophotometry (MASS) before radiotherapy, after radiotherapy (70Gy) and in healthy volunteers. Phosphorus content Results: One edge azure disk method showed that the caries activity of nasopharyngeal carcinoma patients increased after 70Gy irradiation (P 0.01). 2the calcium content in saliva of NPC patients was 63.19 mg / l before radiotherapy and 33.38 mg / L after radiotherapy with 70Gy. After statistical analysis, the difference of saliva calcium content before and after 70Gy was statistically significant (P 0.01). The phosphorus content in saliva of NPC patients was 132.96 mg / l before radiotherapy and 49.18 mg / L after radiotherapy with 70Gy. Statistical analysis showed that there was significant difference in phosphorus content in saliva before radiotherapy and after 70Gy. There was no significant difference in calcium and phosphorus contents in saliva between male and female patients with nasopharyngeal carcinoma (NPC) before radiotherapy and after radiotherapy with 70Gy (P 0.05). There was no significant difference in the contents of calcium and phosphorus in saliva between male and female patients with nasopharyngeal carcinoma before radiotherapy and after 70Gy. There was no significant difference in the contents of calcium in saliva of patients with stage 鈪，

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