OCT与FFA在糖尿病视网膜病变临床前期的应用比较

发布时间：2018-04-24 13:26

  本文选题：光学相干断层扫描 + 眼底荧光血管造影　； 参考：《眼科新进展》2014年07期

【摘要】：目的光学相干断层扫描(optical coherence tomography,OCT)与眼底荧光血管造影(fundus fluorescein angiography,FFA)在糖尿病视网膜病变临床前期的应用比较。方法以2型糖尿病病史10~15 a尚处于DR临床前期的患者76例为研究对象进行OCT和FFA检查,以及糖化血红蛋白(glycosylated hemoglobins A1c,HbAlc)、空腹血糖(fasting blood-glucose,FBG)等检测,记录患者视盘周围视网膜神经纤维层(retinal nerve fiber layer,RNFL)的厚度变化和视网膜微血管的异常情况,结合HbAlc、FBG等检测结果分析两者的关系。结果 OCT或FFA检查异常者共31例(占40.8%),其中19例兼有OCT检查异常(RNFL变薄)和FFA检查异常(出现异常荧光),10例仅表现为OCT检查异常,2例仅表现为FFA检查异常。OCT的阳性检出率(29例,38.2%)高于FFA(21例,27.6%),差异有统计学意义(P≤0.05);OCT检查阳性者29例HbAlc的检测值(6.98±1.01)%高于检查阴性者47例(6.52±0.86)%,差异也有统计学意义(P0.05);OCT检查阳性者FBG检测值(7.51±0.81)mmol·L-1与阴性者(7.38±0.72)mmol·L-1比较差异无统计学意义(P0.05)。结论 OCT和FFA是发现早期DR的有效检查手段,两者相比较OCT更为敏感,而且为无创性检查,更适用于DR筛查和随访复检。
[Abstract]:Objective to compare the application of optical coherence tomography (coherence) and fundus fluorescein angiography (FFA) in diabetic retinopathy. Methods 76 patients with type 2 diabetes mellitus who were still in the pre-clinical stage of Dr for 10 ~ 15 years were examined by OCT and FFA, and the glycosylated hemoglobins A _ 1C ~ (1) HbAlcn and fasting blood glucose (FBG) were measured. The thickness of retinal nerve fiber layer (nerve fiber layerus) and the abnormality of retinal microvessel were recorded, and the relationship between them was analyzed. Results there were 31 cases with abnormal OCT or FFA examination (40.8%), 19 cases with abnormal OCT examination and 10 cases with abnormal FFA examination (10 cases with abnormal OCT and 2 cases with abnormal FFA. Oct). The detection rate of sex was higher in 29 cases (38.2%) than in FFA(21 cases (27.6T). The difference was statistically significant (P 鈮，

本文编号：1796827