鼠神经生长因子结合葛根素对视神经挫伤治疗效果的研究

发布时间：2018-04-25 22:11

本文选题：鼠神经生长因子 + 葛根素　；参考：《黑龙江中医药大学》2010年硕士论文

【摘要】：目的本文通过60例(60眼)视神经挫伤住院患者的临床资料,对鼠神经生长因子结合葛根素治疗视神经挫伤进行临床疗效观察;对其流行病学、诊断、治疗方法等临床资料进行了总结,并对治疗效果进行了比较和探讨。方法本课题对2008年5月-2009年11月在哈尔滨二四二医院眼科、哈医大一院眼科进行治疗的60例视神经挫伤患者建立临床观察表,进行临床观察研究,随机将视神经挫伤患者60例(60眼)分为2组,治疗组30例(30眼),对照组30例(30眼)。治疗组主要采用鼠神经生长因子30μg,用2 mL生理氯化钠溶液或注射用水溶解,一日一次肌肉注射,平均治疗21天,葛根素250mL一日一次静脉注射,同时常规用药治疗。对照组除不加用鼠神经生长因子,葛根素外,其他用药同治疗组,通过视力、视觉诱发电位及视野对两种治疗方法在治疗前后及两组间进行比较。结果(1)鼠神经生长因子结合葛根素治疗视神经挫伤总有效率为86.7% ,对照组为63.3% ,两组比较有显著性差异具有统计学意义(χ2=3.675,P0.05)。(2)视觉诱发电位方面,通过治疗前后及两组间P100潜伏期及幅值进行比较,两组患者治疗前对比无统计学意义(p0.05),两组患者治疗后比较有统计学意义(P0.05),治疗组治疗后优于对照组治疗后,并且两组患者治疗后优于两组患者治疗前,差异有统计学意义(p0.05)。(3)在视野方面,通过治疗前后及两组间视野平均光敏度及平均缺损度进行比较,两组患者治疗前对比无统计学意义(p0.05),两组患者治疗后比较有统计学意义(P0.05),治疗组治疗后优于对照组治疗后,并且两组患者治疗后优于两组患者治疗前,差异有统计学意义(p0.05)。结论1鼠神经生长因子结合葛根素对视神经挫伤的治疗具有肯定疗效,值得推广。2相对于视力检查,VEP是客观、准确、临床实用性很强的诊察方法。3常规治疗基础上加用鼠神经生长因子结合葛根素对视神经挫伤的疗效优于单纯的常规激素治疗;
[Abstract]:Objective to observe the clinical efficacy of nerve growth factor (NGF) combined with puerarin in the treatment of optic nerve contusion in 60 patients (60 eyes) with optic nerve contusion. The clinical data such as treatment methods were summarized, and the therapeutic effects were compared and discussed. Methods from May 2008 to November 2009, 60 patients with optic nerve contusion were treated in Harbin No.2 Hospital. 60 cases of optic nerve contusion were randomly divided into two groups: 30 eyes in the treatment group and 30 eyes in the control group. The treatment group was treated with nerve growth factor (NGF) 30 渭 g, dissolved with 2 mL physiological sodium chloride solution or injected with water, intramuscularly injected once a day for an average of 21 days, puerarin 250mL was injected intravenously once a day, and treated with routine medication. In the control group, the visual acuity, visual evoked potential and visual field were compared between the two groups before and after treatment, except for rat nerve growth factor and puerarin. Results 1) the total effective rate of nerve growth factor (NGF) combined with puerarin in the treatment of optic nerve contusion was 86.7%, and that in the control group was 63.3%. The latency and amplitude of P100 before and after treatment were compared between the two groups. There was no significant difference between the two groups before and after treatment, but there was significant difference between the two groups after treatment. The treatment group was better than the control group after treatment. After treatment, the difference between the two groups was statistically significant (P < 0.05). The visual field of the two groups was compared by comparing the average Guang Min degree and the average defect degree before and after treatment, and the difference between the two groups before and after treatment. There was no significant difference between the two groups before and after treatment, there was significant difference between the two groups after treatment, the treatment group was better than the control group after treatment, and the two groups were better than the two groups before treatment, the difference was statistically significant. Conclusion 1Rat nerve growth factor combined with puerarin has positive curative effect on optic nerve contusion, which is worth popularizing compared with visual acuity examination and VEP is objective and accurate. On the basis of routine treatment of rat nerve growth factor combined with puerarin, the effect of routine therapy on optic nerve contusion was better than that of routine hormone therapy.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R779.1

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