不同程度阻塞性睡眠呼吸暂停低通气综合征患者颈动脉内膜中层厚度和炎症因子的变化及相关性研究

发布时间：2018-04-27 22:14

本文选题：阻塞性睡眠呼吸暂停低通气综合征 + 颈动脉内膜中层厚度　；参考：《实用医学杂志》2014年12期

【摘要】：目的:探讨不同程度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者颈动脉内膜中层厚度(CIMT)和血浆白细胞介素-6(IL-6)、超敏C反应蛋白(hsCRP)的变化及其相关性。方法 :选择OSAHS患者57例,根据睡眠呼吸暂停低通气指数(AHI)分为轻度组17例、中度组18例、重度组22例,测定各组夜间最低血氧饱和度(LSaO2)、平均SaO2(MSaO2)、CIMT及IL-6和hsCRP血浆浓度,采用偏相关分析法分析CIMT、IL-6、hsCRP与AHI、LSaO2、MSaO2之间的相关性。结果:中、重度OSAHS组CIMT、IL-6、hsCRP水平比轻度组明显升高,差异有统计学意义(P0.01);CIMT与血浆IL-6、hsCRP水平及AHI显著正相关,与LSaO2、MSaO2负相关;IL-6、hsCRP水平与AHI显著正相关,与LSaO2、MSaO2负相关。结论:中重度OSAHS患者CIMT、血浆IL-6及hsCRP水平明显增加,CIMT与炎症因子及睡眠呼吸监测指标密切相关,提示低氧血症的严重程度可能导致OSAHS患者炎症因子增加及动脉粥样硬化的发生。
[Abstract]:Objective: to investigate the changes of carotid intima-media thickness (IMT) and plasma interleukin-6 (IL-6), hypersensitive C-reactive protein hsCRP (hsCRP) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) with different degrees of obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: 57 patients with OSAHS were divided into mild group (n = 17), moderate group (n = 18) and severe group (n = 22) according to sleep apnea hypopnea index. The correlation between IL-6 hsCRP and MSaO2 was analyzed by partial correlation analysis. Results: the level of IL-6 hsCRP in moderate and severe OSAHS group was significantly higher than that in mild group. The difference was statistically significant. There was a significant positive correlation between CIMT and plasma IL-6 hsCRP level and AHI level, a negative correlation between IL-6 hsCRP level and AHI, and a negative correlation between IL-6 hsCRP level and LSaO2mSaO2 level. Conclusion: the levels of CIMT, plasma IL-6 and hsCRP in moderate and severe OSAHS patients are significantly increased. CIMT is closely related to inflammatory factors and sleep respiratory monitoring, suggesting that the severity of hypoxemia may lead to the increase of inflammatory factors and the occurrence of atherosclerosis in OSAHS patients.
【作者单位】：湖北省襄阳市中心医院;湖北文理学院附属医院呼吸内科;湖北文理学院附属医院心内科;湖北文理学院附属医院超声科;
【分类号】：R766

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