声带息肉与血脂相关性研究

发布时间：2018-04-29 00:40

本文选题：ApoA-I + HDL-C　；参考：《福建医科大学》2013年硕士论文

【摘要】：目的通过回顾性病例对照研究，观察血清中血脂在声带息肉患者中变化，探讨在声带息肉中血脂的改变及其相关性。方法选取2010年1月至2012年12月期间入住福建医科大学附属第一医院耳鼻咽喉科诊断为声带息肉的患者为实验组，对照组选取2010年1月至2012年12月期间于福建医科大学附属第一医院体检的正常人。测定血清中总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A-I（ApoA-I）。数据运用SPSS18.0统计学软件对实验组和对照组各数据进行分析，计算出P值(取P0.05为差异有显著性)。结果男性组中非吸烟声带息肉组与非吸烟正常人组HDL-C、ApoA-I差异有统计学意义（P0.05）；吸烟声带息肉组与非吸烟声带息肉组HDL-C、ApoA-I差异有统计学意义（P0.05）；吸烟声带息肉组与吸烟正常人组ApoA-I差异有统计学意义（P0.05），HDL-C差异没有统计学意义（P0.05）；正常非吸烟组与正常人吸烟组HDL-C、ApoA-I差异有统计学意义（P0.05）。女性组中声带息肉组与正常人组ApoA-I差异有统计学意义（P0.05），HDL-C差异没有统计学意义（P0.05）。HDL-C、ApoA-I行Logistic回归分析显示ApoA-I与声带息肉呈负相关(r=-3.742，OR=0.024，，P0.05)，HDL-C与声带息肉相关性没有统计学意义（P0.05）。结论声带息肉患者血清中ApoA-I下降，ApoA-I与声带息肉形成存在一定的相关性。
[Abstract]:Objective to observe the changes of serum lipids in patients with vocal cord polyps by retrospective case-control study, and to explore the changes of serum lipids in vocal cord polyps and their correlation. Methods from January 2010 to December 2012, the patients who were diagnosed as vocal cord polyps in the Department of Otolaryngology, first affiliated Hospital of Fujian Medical University were selected as experimental group. The control group was selected from January 2010 to December 2012 in the first affiliated Hospital of Fujian Medical University. Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A (A), ApoA (I) were determined. SPSS18.0 software was used to analyze the data of the experimental group and the control group, and the P value was calculated (P 0.05 was taken as the significant difference). Results there were significant differences in HDL-CnApoA-I between non-smoking vocal cord polyp group and non-smoking normal person group in male group, HDL-CfU ApoA-I difference in non-smoking vocal cord polyp group and non-smoking vocal cord polyp group in smoking vocal cord polyp group, and normal smoking in smoking vocal cord polyp group. There was no significant difference in HDL-C between the two groups (P 0.05), but there was a significant difference in HDL-Cn ApoA-I between the normal nonsmoking group and the normal smoking group (P 0.05). There was no significant difference in ApoA-I between the vocal cord polyp group and the normal control group. There was no significant difference in HDL-C between the vocal cord polyp group and the normal control group. The Logistic regression analysis showed that there was a negative correlation between ApoA-I and the vocal cord polyp. There was no significant correlation between the ApoA-I and the vocal cord polyp. Conclusion there is a certain correlation between ApoA-I and vocal cord polyp formation in patients with vocal cord polyps.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R767.4

【参考文献】