13例硬皮病眼部表现临床分析

发布时间：2018-04-29 07:06

本文选题：硬皮病 + 自身免疫性疾病　；参考：《眼科》2015年05期

【摘要】：目的探讨硬皮病有眼部表现患者的临床特点。设计回顾性病例系列。研究对象2008年12月至2013年2月北京同仁医院风湿免疫科住院的13例伴眼部受累硬皮病患者。方法回顾性分析13例累及眼部的硬皮病患者的临床资料,总结该病临床及实验室特点。主要指标硬皮病患者的各种眼部表现占总病例数的百分比。结果 13例硬皮病患者均为女性;眼部受累的平均发病年龄为(43±12.2)岁,硬皮病平均病程(6.1±5.1)年,眼病平均病程(1.4±1.9)年。系统型硬皮病11例(84.6%);局限型硬皮病2例(15.4%)。以眼部症状为首发表现者7例(53.8%)。干燥性角结膜炎7例(53.8%),眼睑皮肤改变3例(23.1%)和青光眼3例(23.1%)为常见眼部表现;其他表现依次为视神经炎、角膜炎、虹睫炎(各2例,占15.4%),巩膜炎、白内障、葡萄膜炎、中心性浆液性脉络膜视网膜病变、眼球内陷、泪腺炎(各1例,占7.7%)。未发现眼部受累与全身表现及实验室指标相关。结论各型硬皮病均可出现眼部受累,其中以系统型硬皮病为主。硬皮病眼部表现多样,受累范围广泛,其中以干燥性角结膜炎最常见。
[Abstract]:Objective to investigate the clinical features of scleroderma with ocular manifestations. A retrospective case series was designed. 13 patients with ocular involvement in the Department of Rheumatology of Beijing Tongren Hospital from December 2008 to February 2013 were studied. Methods the clinical data of 13 patients with ocular scleroderma were analyzed retrospectively, and the clinical and actual conditions of the disease were summarized. The percentage of ocular manifestations of scleroderma patients accounted for the percentage of total cases. Results all 13 cases of scleroderma were women; the average age of onset of ocular involvement was (43 + 12.2) years, average course of scleroderma (6.1 + 5.1) years, average course of disease (1.4 + 1.9) years, systemic scleroderma 11 cases (84.6%), and localized scleroderma 2 cases. (15.4%) 7 cases (53.8%) with ocular symptoms as the first manifestation. 7 cases of dry keratoconjunctivitis (53.8%), 3 cases of eyelid skin change (23.1%) and 3 cases of glaucoma (23.1%) as common ocular manifestations; other manifestations were optic neuritis, keratitis, siphon (2 cases, 15.4%), sclera, cataract, uveitis and central serous choroidal retina. Membrane lesions, invagination, and lacrimal gland inflammation (1 cases, accounting for 7.7%). No eye involvement was found to be associated with systemic manifestations and laboratory indicators. Conclusion all types of scleroderma may be involved in eye involvement, mainly systemic scleroderma. Scleroderma has a wide range of ocular manifestations and a wide range of involvement, among which dry keratoconjunctivitis is the most common.

【作者单位】：首都医科大学附属北京同仁医院风湿免疫科;
【分类号】：R593.25;R771.3

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