新疆维、汉族鼻咽癌患者HLA-DRB1等位基因多态性的研究与分析

发布时间：2018-04-29 07:56

本文选题：鼻咽癌 + HLA-DRB　；参考：《上海交通大学学报(医学版)》2015年09期

【摘要】：目的探讨人类白细胞抗原HLA-DRB1等位基因多态性与新疆地区维、汉族鼻咽癌发病的关系。方法采用聚合酶链反应-序列特异性引物(PCR-SSP)技术,对55例汉族、41例维族鼻咽癌患者与62名汉族、35名维族健康者作为对照进行HLA-DRB1位点基因分型,比较两组间等位基因频率分布差异。结果1汉族鼻咽癌组DRB1*08基因频率高于健康对照组(P0.05),DRB1*11、DRB1*15基因频率低于健康对照组(P0.05),P值经Bonferroni校正后,HLA-DRB1位点基因频率差异均无统计学意义(Pc0.05)。2维族鼻咽癌组与健康对照组HLA-DRB1位点基因频率差异无统计学意义(Pc0.05)。3汉族鼻咽癌组DRB1*08、DRB1*09、DRB1*12基因频率高于维族鼻咽癌组(P0.05),DRB1*07、DRB1*13基因频率低于维族鼻咽癌组(P0.05)。经Bonferroni校正后DRB1*07(Pc=0.002)、DRB1*08(Pc=0.009)、DRB1*09(Pc=0.039)基因频率差异具有统计学意义。结论新疆维、汉族鼻咽癌患者HLA-DRB1位点等位基因频率存在差异;HLA-DRB1位点基因多态性与新疆维、汉族鼻咽癌发病可能无相关性。
[Abstract]:Objective to investigate the relationship between polymorphisms of human leukocyte antigen (HLA-DRB1) alleles and the incidence of nasopharyngeal carcinoma (NPC) in Xinjiang. Methods Polymerase chain reaction-sequence specific primer PCR-SSP was used to type HLA-DRB1 loci in 55 patients with nasopharyngeal carcinoma of Uygur nationality and 62 healthy controls. To compare the frequency distribution of alleles between the two groups. Results 1 the frequency of DRB1*08 gene in nasopharyngeal carcinoma of Han nationality was higher than that in healthy control group. The frequency of DRB1*08 gene was lower than that in healthy control group. There was no significant difference in the frequency of HLA-DRB1 locus gene between Uygur nasopharyngeal carcinoma group and healthy control group after Bonferroni correction. There was no significant difference in the frequency of DRB1 / 09 / DRB1m12 gene in NPC patients of Han nationality (P c 0.05.3). The frequency of DRB1m12 gene in DRB08DRB1m12 gene was higher than that in Uygur nasopharyngeal carcinoma group (P 0.05). The frequency of DRB1m13 gene was lower than that in Uygur nasopharyngeal carcinoma group (P 0.05). After Bonferroni correction, there was a significant difference in the frequency of DRB1 07 (DRB1 0. 002) and DRB1 (0. 009) PcC (0. 039) gene. Conclusion the allelic frequency of HLA-DRB1 locus is different between Xinjiang Uygur and Han nationality patients with nasopharyngeal carcinoma. The polymorphism of HLA-DRB1 locus is not related to Xinjiang dimension. There may be no correlation between the occurrence of nasopharyngeal carcinoma in Han nationality.
【作者单位】：新疆医科大学附属肿瘤医院头颈放疗科;
【基金】：新疆维吾尔自治区自然科学基金(2011211B22) 国家自然科学基金(81160327)~~
【分类号】：R739.63

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