平阳霉素联合地塞米松注射治疗咽喉血管瘤的疗效观察

发布时间：2018-04-29 20:12

本文选题：平阳霉素 + 地塞米松　；参考：《临床耳鼻咽喉头颈外科杂志》2014年18期

【摘要】：目的:评价平阳霉素联合地塞米松局部注射治疗咽喉血管瘤的效果。方法:对我科2007-01-2012-12期间收治的资料完整的112例咽喉血管瘤患者进行回顾性分析。全部患者均接受平阳霉素、地塞米松混合液局部注射,以电子喉镜观察瘤体大小变化作为主要评价指标。结果:本组患者接受药物注射治疗1~9次,平均4.3次,全身麻醉下实施手术253例,局部麻醉实施手术109例。痊愈46例(41.1%),显效55例(49.1%),好转11例(9.8%),总有效率100%。3例行预防性气管切开,1个月后均顺利拔管。4例患者复查胸片出现轻度肺间质纤维化表现,无功能障碍。结论:平阳霉素联合地塞米松局部注射治疗咽喉血管瘤效果显著,安全性较高,但仍应注意化疗药物本身毒副作用的发生,咽喉注射时应密切观察呼吸道水肿的发生及发展,防止喉梗阻的发生,必要时行预防性气管切开。
[Abstract]:Objective: to evaluate the efficacy of pingyangmycin combined with dexamethasone in the treatment of pharyngeal and laryngeal hemangioma. Methods: 112 cases of pharyngeal and laryngeal hemangioma treated in our department from January to December 2007 were retrospectively analyzed. All the patients were treated with pingyangmycin and dexamethasone. The changes of tumor size were observed by electronic laryngoscope. Results: the patients were treated with drug injection for 9 times (average 4.3 times). 253 cases were operated under general anesthesia and 109 cases were operated under local anesthesia. 46 cases recovered 41.1%, 55 cases showed remarkable effect, 11 cases got improvement and 9.8%. The total effective rate was 100.3 cases with prophylactic tracheotomy. After 1 month, all the cases had mild pulmonary interstitial fibrosis on chest radiographs without dysfunction. Conclusion: Pingyangmycin combined with local injection of dexamethasone is effective and safe in the treatment of laryngeal hemangioma. However, the occurrence of toxic and side effects of chemotherapeutic drugs should still be paid attention to, and the occurrence and development of respiratory edema should be observed closely during the injection of pingyangmycin and dexamethasone. To prevent laryngeal obstruction, preventive tracheotomy is necessary.
【作者单位】：第四军医大学西京医院耳鼻咽喉头颈外科;
【分类号】：R739.6

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