Survivin、Cyclin D1和nm23-H1蛋白表达程度与鼻咽癌放射治疗预后的相关关系

发布时间：2018-04-30 12:24

本文选题：鼻咽癌 + Survivin　；参考：《中国医科大学》2010年硕士论文

【摘要】： 目的通过临床病例随访研究,观察72例鼻咽癌患者的生存情况,了解鼻咽癌组织中Survivin, Cyclin D1和nm23-H1蛋白表达与放疗预后的关系。方法收集2000年1月至2004年5月间在我科初治、有完整临床及病理资料的鼻咽癌72例,对患者治疗前鼻咽部病理标本进行S—P法免疫组织化学技术检测其中Survivin, Cyclin D1和nm23-H1蛋白表达,并临床随访5年以上结果 (1)72例鼻咽癌患者3年生存率为65.2%,5年生存率为44.4%。 (2) Survivin蛋白阳性表达率Ⅰ期为75.0%(3/4),与放疗预后无统计学意义(P0.05)；Ⅱ期为64.3%(18/28),有统计学意义(P0.05)；Ⅲ期为33.3%(11/33),有统计学意义；Ⅳa期为71.4%(5/7),有统计学意义。 (3) Cyclin D1蛋白阳性表达率Ⅰ期为50.0%(2/4),提示与放疗预后无统计学意义(P0.05)；Ⅱ期的阳性表达率为67.9%(19/28),提示有统计学意义(P0.05)；Ⅲ期的阳性率为48.5%(16/33),有统计学意义；Ⅳa期的阳性率为71.4%(5/7),有统计学意义。 (4)Nm23-H1蛋白阳性表达率Ⅰ期阳性表达为100.0%(4/4),与放疗预后无统计学意义(P0.05)；Ⅱ期为64.39%(18/28),提示有统计学意义(P0.05)；Ⅲ期为72.7%(24/33),有统计学意义；Ⅳa期的阳性率为57.1%(4/7),有统结论鼻咽癌组织中Survivin、Cyclin D1蛋白表达与放疗预后呈负相关,nm23-H1蛋白的表达程度与放疗预后呈正相关。可作为鼻咽癌患者预测放疗预后的一个独立因素。
[Abstract]:objective
To observe the survival of 72 patients with nasopharyngeal carcinoma and to understand the relationship between the expression of Survivin, Cyclin D1 and nm23-H1 protein and the prognosis of radiotherapy in nasopharyngeal carcinoma.
Method
72 cases of nasopharyngeal carcinoma with complete clinical and pathological data were collected from January 2000 to May 2004 with complete clinical and pathological data. The S P immunohistochemical technique was used to detect the expression of Survivin, Cyclin D1 and nm23-H1 protein in the pathological specimens of the nasopharynx before treatment, and the results were followed up for more than 5 years.
(1) the 3 year survival rate of 72 nasopharyngeal carcinoma patients was 65.2%, and the 5 year survival rate was 44.4%.
(2) the positive expression rate of Survivin protein was 75% (3/4), and was not statistically significant with the prognosis of radiotherapy (P0.05), and 64.3% (18/28) in stage II (P0.05), and 33.3% (11/33) in stage III, and 71.4% (5/7) in stage IV A, with statistical significance.
(3) the positive expression rate of Cyclin D1 protein was 50% (2/4), indicating no statistical significance with radiotherapy (P0.05), and the positive rate in stage II was 67.9% (19/28), indicating a statistical significance (P0.05), and the positive rate in stage III was 48.5% (16/33), and the positive rate in stage IV A was 71.4% (5/7), with statistical significance.
(4) the positive expression of Nm23-H1 protein positive expression was 100% (4/4), and was not statistically significant with the prognosis of radiotherapy (P0.05), and 64.39% (18/28) in stage II (P0.05), and 72.7% (24/33) in stage III; the positive rate in stage IV A was 57.1% (4/7), and there was a significant difference.
conclusion
The expression of Survivin, Cyclin D1 protein in nasopharyngeal carcinoma is negatively correlated with the prognosis of radiotherapy, and the expression of nm23-H1 protein is positively correlated with the prognosis of radiotherapy. It can be used as an independent prognostic factor for patients with nasopharyngeal carcinoma to predict the prognosis of radiotherapy.

【学位授予单位】：中国医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R739.63

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