高透氧夜戴式角膜塑型片对角膜内皮细胞的影响

发布时间：2018-05-02 17:37

本文选题：夜戴式角膜塑型 + 近视　；参考：《安徽医科大学》2011年硕士论文

【摘要】：研究背景现代近视普遍率越来越高,度数也越来越朝高度数发展。在社会竞争的压力下,学龄前的提早学习,不管是术科或学科都趋之若鹜。父母亲为了一句”不要输在起跑点”,一窝蜂式的去补习、去学特殊技能。眼睛在提早过度使用之下,近视也提早出视。视力不良会影响到日常生活,使上课学习能力下降。矫正方式最为普遍的就是戴一般的光学眼镜,其次还有隐形眼镜、屈光手术治疗、角膜塑型治疗。各种视力矫正方式都有它的优缺点,不同年龄层、不同工作性质各有所需求。以学童来说除了方便还要考虑安全性,光学眼镜的方便性高,戴在活力十足的学童脸上就有些不便。近年来为了延迟儿童近视快速增加并且矫正视力,夜戴式角膜塑型术日渐普遍。日戴式高透氧隐形眼镜长时间配戴之下,多少都会造成角膜缺氧。而夜戴式角膜塑型片是否也一样让角膜缺氧或有其它变化,值得进一步探讨。目的本实验使用角膜影像分析仪,分析学童配戴夜戴式角膜塑型片前和配戴两年后其的,依据其六角形细胞及细胞密度的变化来推论角膜在配戴夜戴式角膜塑型片后所受的影响。方法1研究人群：选取7岁到15岁的学童,14名男性,20名女性,无眼部疾病。 2近视度数-1.0D到-5.0D,散光0.00D到-1.75D3配戴夜戴式角膜塑型片前以MONMET角膜曲度计测量左右眼角膜曲度,TOPCON SP-3000P角膜影像分析仪测量其角膜内皮的六角形细胞出现频率及细胞密度,二年后再同样一次。 4第一次配戴夜戴式角膜塑型片后三天首次追踪,如果正常,7天后第二次追踪检查,14天后第三次检查,1个月后第四次检查,如果无异常,日后每3个月检查一次。结果1受测者34名都正常配戴,其中5名在这2年内曾经因为过敏性结膜炎而暂时停止配戴2天,愈后正常配戴。 2受测者左右眼配戴夜戴式角膜塑型片前、后2年的角膜内皮细胞密度无统计学上的差异(p=0.230paired t test)。 3治疗前角膜内皮六角形细胞出现频率与治疗后2年角膜内皮六角形细胞出现频率无统计学上的差异(p=0.131paired t test)。结论 1.配戴夜戴式角膜塑型可以暂时达到减少近视度数的效果。 2配戴夜戴式角膜塑型2年内对角膜内皮细胞的形态与细胞密度无明显的影响。 3长期配戴夜戴式角膜塑型对角膜的影响仍然须要进一步的探讨。
[Abstract]:Background the prevalence and degree of modern myopia are increasing. Under the pressure of social competition, preschool early learning, be it technical or academic. For the sake of saying "Don't lose at the starting point", parents swarm to study and learn special skills. Eyes under early overuse, myopia also early out of sight. Poor eyesight can affect daily life and reduce the ability to learn in class. The most common correction is to wear general optical glasses, followed by contact lenses, refractive surgery, corneal plastic treatment. All kinds of visual acuity correction methods have their own advantages and disadvantages, different age groups, different working properties have their own needs. In addition to convenience and safety considerations, optical glasses are highly convenient and inconvenient to wear on the faces of energetic schoolchildren. In recent years, in order to delay the rapid increase of myopia and correct vision in children, night-wear keratoplasty is becoming more and more common. Wearing high oxygen-permeable contact lenses for a long time can cause corneal anoxia. It is worth further study whether the night-wear keratoplasty also causes anoxia or other changes in the cornea. Purpose In this experiment, the corneal image analyzer was used to analyze the influence of the children on the cornea after wearing the night-wear keratoplasty and two years later. According to the changes of the hexagonal cells and cell density, the influence of the cornea after wearing the night-wear corneal plastic film was deduced. Methods 1 A total of 14 male and 20 female children aged 7 to 15 years were enrolled in the study. (2) myopia degree -1.0D to -5.0D, astigmatism 0.00D to -1.75D3 was used to measure the frequency and cell density of hexagonal cells in corneal endothelium by MONMET keratometer before wearing corneal plastic film. Two years later again. (4) for the first time, 3 days after wearing the night-wear keratoplasty, if normal 7 days later, the second follow-up examination was followed by the third one after 14 days, the fourth time after one month, and if there was no abnormality, every three months in the future. Results (1) 34 subjects were normally worn, 5 of them had been temporarily stopped wearing for 2 days because of allergic conjunctivitis. 2There was no significant difference in the density of corneal endothelial cells between the left and right eyes of the subjects after 2 years before wearing night keratoplasty, and there was no significant difference in the density of corneal endothelial cells between the two groups (P < 0. 230 paired t test). 3There was no significant difference between the frequency of corneal endothelial hexagonal cells before treatment and that of corneal endothelial hexagonal cells 2 years after treatment. Conclusion 1. Wearing night-wearing keratoplasty can temporarily reduce myopia. 2 the morphology and cell density of corneal endothelial cells were not significantly affected by wearing night-wear keratoplasty for 2 years. 3 the effect of long-term wearing night-wear keratoplasty on cornea still needs further discussion.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R772

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