耳后注射甲强龙治疗难治性突发性聋疗效分析

发布时间：2018-05-06 22:15

本文选题：耳后注射 + 突发性聋　；参考：《中华耳科学杂志》2014年03期

【摘要】：目的探讨耳后注射甲强龙对难治性突发性聋的治疗效果。方法 45例经全身糖皮质激素治疗后未痊愈的全部频率下降的突发性聋患者,随机分为两组:对照组(23例)仅给予降低纤维蛋白原、改善微循环及营养神经等常规治疗,耳后组(22例)在此治疗基础上给予耳后注射甲泼尼龙琥珀酸钠20mg,隔日1次,共3次。结果给药后两周:耳后组及对照组总有效率分比为50%(11/22),30.4%(7/23);显效率分别为22.7%(5/22),0。耳后组气导平均听阈提高20.01±14.11dB,对照组提高10.47±8.53dB,两组之间有显著差异(P=0.0087);耳后组低频(250Hz,500Hz)气导平均听阈提高更显著,分别提高24.09±16.95dB;25.23±18.29dB;而对照组低频(250Hz,500Hz)分别提高10.43±9.87dB;11.52±9.46dB;两组之间有显著差异(P=0.0018,P=0.0027)。结论耳后注射甲强龙治疗难治性突发性聋,疗效显著,且对低频听力提高的效果更佳。
[Abstract]:Objective to investigate the therapeutic effect of posterior auricular injection of a strong dragon on refractory sudden deafness. Methods 45 cases of sudden deafness who had not recovered completely after the treatment of systemic glucocorticoid were divided into two groups randomly: the control group (23 cases) was given only the reduction of fibrinogen, improved microcirculation and nutritional nerve routine treatment, and after the ear group (22 cases). On the basis of this treatment, the post ear injection of methylprednisolone sodium succinate 20mg was given 1 times a day for 3 times. The total effective ratio was 50% (11/22), 30.4% (7/23) and 22.7% (5/22) in the post ear group and the control group. The average hearing threshold of the group after 0. ears was increased by 20.01 + 14.11dB, and the control group was increased by 10.47 + 8.53dB, and two groups were among the two groups. Significant difference (P=0.0087); the average hearing threshold of low frequency (250Hz, 500Hz) increased by 24.09 + 16.95dB and 25.23 + 18.29dB respectively, while the low frequency (250Hz, 500Hz) in the control group was 10.43 + 9.87dB and 11.52 + 9.46dB, respectively. There were significant differences between the two groups (P=0.0018, P=0.0027). Conclusion the posterior injection of a strong dragon in the treatment of refractory sudden deafness The effect is remarkable and the effect on improving low frequency hearing is better.

【作者单位】：北京大学人民医院;
【基金】：首发基金联合攻关项目《耳后给药与鼓室给药的临床疗效及作用途径的对照研究》20091015
【分类号】：R764.437

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