血清25羟维生素D3水平与2型糖尿病视网膜病变的关系研究

发布时间：2018-05-09 22:07

本文选题：型糖尿病 + 糖尿病视网膜病变　；参考：《眼科新进展》2014年06期

【摘要】：目的探讨血清25羟维生素D3[25-(OH)D3]水平与2型糖尿病视网膜病变(diabetic retinopathy,DR)的关系。方法选取144例2型糖尿病患者,分为无DR组(NDR组)50例、非增生期DR组(NPDR组)48例和增生期DR组(PDR组)46例,并选取同期来本院体检的46例健康者为对照组(NDM组)。对每位患者进行临床资料收集及常规生化指标检测,采用电化学发光法检测所有受试者血清25-(OH)D3水平。结果 NDR组患者血清25-(OH)D3浓度为(28.10±10.23)ng·mL-1,明显低于NDM组的(31.59±9.12)ng·mL-1,NPDR组患者血清25-(OH)D3浓度为(25.18±10.56)ng·mL-1,明显低于NDR组,而PDR组患者血清25-(OH)D3浓度为(22.29±10.82)ng·mL-1,又明显低于NPDR组,差异均有统计学意义(均为P0.05)。Pearson相关分析显示,血清25-(OH)D3水平与病程、HbA1C、血肌酐均呈统计学上的负相关(r=-0.16、-0.19、-0.22,均为P0.05)。结论 2型DR患者血清25-(OH)D3水平明显降低,且与DR的严重程度存在关联。
[Abstract]:Objective to investigate the relationship between serum 25 hydroxyvitamin D 3 [25-(OH)D3] and type 2 diabetic retinopathy. Methods 144 patients with type 2 diabetes were divided into three groups: NDR group (n = 50), NPDR group (n = 48) and PDR group (n = 46). The clinical data were collected and routine biochemical indexes were detected. The serum 25-(OH)D3 level was measured by electrochemiluminescence (ECL). Results the level of serum 25-(OH)D3 in NDR group was 28.10 卤10.23)ng mL-1, which was significantly lower than that in NDM group (31.59 卤9.12)ng mL-1), which was significantly lower than that in NDR group (25.18 卤10.56)ng mL-1), while that in PDR group was 22.29 卤10.82)ng mL-1, which was significantly lower than that in NPDR group. The difference was statistically significant (all P0.05).Pearson correlation analysis showed that the serum 25-(OH)D3 level was negatively correlated with HbA1Cand creatinine in all patients (P 0.05). Conclusion the serum 25-(OH)D3 level in patients with type 2 Dr was significantly decreased and correlated with the severity of Dr.
【作者单位】：新乡医学院第三附属医院内分泌科;新乡医学院免疫学教研室;
【分类号】：R587.2;R774.1

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