bFGF对LASIK术后角膜知觉恢复和角膜神经修复的影响

发布时间：2018-05-10 13:24

  本文选题：成纤维细胞生长因子 + 角膜中央知觉　； 参考：《眼科新进展》2014年05期

【摘要】：目的研究重组牛碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)对准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)后角膜神经修复和角膜知觉恢复的作用。方法将LASIK术后患者随机分入治疗组(treatment group,TG)和对照组(control group,CG)进行临床对比观察,TG组20例(40眼),CG组18例(36眼)。TG组应用r-bFGF滴眼液和眼用凝胶(贝复舒),CG组应用玻璃酸钠滴眼液(爱丽),均为每天4次,连续给药3个月。于术后1周、1个月、3个月、6个月对比两组角膜中央知觉和角膜中央上皮下神经纤维恢复情况。结果术后各时间点两组间裸眼视力比较差异无统计学意义(均为P0.05),术后6个月时两组裸眼视力均≥5.0。术后1周、1个月、3个月、6个月时角膜知觉TG组为13.67±5.71、21.67±5.77、31.17±7.51、51.33±4.54,CG组为13.50±4.76、19.83±4.64、25.83±11.94、45.83±7.78,术后1周、1个月时两组比较差异无统计学意义(P=0.087、0.094),术后3个月、6个月时TG组优于CG组(P=0.005、0.018),术后6个月时两组角膜知觉均未达到术前水平。术后1周、1个月、3个月、6个月时角膜神经纤维密度TG组为(331.07±410.81)μm·mm-2、(531.53±516.87)μm·mm-2、(1924.73±1160.27)μm·mm-2、(4284.07±2372.23)μm·mm-2,CG组为(319.53±509.17)μm·mm-2、(486.20±611.48)μm·mm-2、(952.87±717.92)μm·mm-2、(2062.87±2417.16)μm·mm-2,术后1周、1个月时两组比较差异无统计学意义(P=0.801、0.072),术后3个月、6个月时TG组角膜神经纤维密度高于CG组(P=0.033、0.000),术后6个月时两组角膜神经纤维密度仍明显低于术前。结论 bFGF对LASIK术后角膜神经修复和角膜知觉恢复具有促进作用。
[Abstract]:Objective to study the effect of recombinant bovine basic fibroblast growth factor (fibroblast growth) on corneal nerve repair and corneal perception recovery after laser in situ keratomileusissis (LASIK) with laser in situ keratomileusis (LASK). Methods the patients after LASIK were randomly divided into treatment group (TG) and control group (control group CGG). The clinical observation was made between 20 cases of TG group (20 cases) and 40 eyes of CG group (18 cases, 36 eyes) were treated with r-bFGF eye drops and eye gels (group B, C + C) were treated with sodium hyaluronate drop (n = 18, n = 36, n = 18, n = 36, n = 30). Liquid (Alicia), 4 times a day, The drug was given continuously for 3 months. At 1 week, 1 month, 3 months and 6 months after operation, the corneal central perception and the recovery of the central subepithelial nerve fibers were compared between the two groups. Results there was no significant difference in the naked visual acuity between the two groups at each time point after operation (all P 0.05). At 6 months after operation, the naked visual acuity of the two groups was 鈮，

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