鼻咽癌治疗后远处转移模式分析

发布时间：2018-05-10 19:12

  本文选题：鼻咽肿瘤 + 远处转移　； 参考：《广东医学》2014年05期

【摘要】：目的分析304例首程治疗的无远处转移鼻咽癌患者治疗后远处转移部位和时间间隔,探讨鼻咽癌远处转移模式。方法收集排除远处转移及病理确诊后行根治性治疗鼻咽癌患者1 338例。治疗后其中304例随访发现远处转移。采用Kaplan-Meier法计算总生存率。结果鼻咽癌患者远处转移占治疗失败患者总数的65.2%;中位间隔时间为18个月。Ⅰ、Ⅱ、Ⅲ和Ⅳ期远处转移例数分别占各期总数的0、12.6%、23.2%和31.5%。T1、T2、T3、T4和N0、N1、N2、N3期转移例数分别占各期总数的20.1%、20.5%、27%、24.6%和11.3%、22.6%、23.7%、41.1%。远处转移最常见部位为骨、肝、肺。出现在治疗后1、2、3、4年内分别占5年远处转移总数的35.5%、63.8%、83.2%、94.4%。结论远处转移为鼻咽癌治疗失败最主要原因且多数发生在治疗后3年内。临床分期尤其是N分期的严重程度与远处转移密切相关。
[Abstract]:Objective to analyze the location and time interval of distant metastasis in 304 patients with nasopharyngeal carcinoma without distant metastasis after first course treatment, and to explore the pattern of distant metastasis of nasopharyngeal carcinoma. Methods 1 338 patients with nasopharyngeal carcinoma were treated with radical therapy after distant metastasis and pathological diagnosis. After treatment, 304 cases were followed up with distant metastasis. The overall survival rate was calculated by Kaplan-Meier method. Results distant metastasis accounted for 65.2% of the total number of patients with nasopharyngeal carcinoma and the median interval was 18 months. The number of distant metastases in stages 鈪，

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