CDFI检测阻塞型睡眠呼吸暂停综合征患者的眼底血流变化及与血氧饱和度的相关性研究

发布时间：2018-05-12 18:56

本文选题：阻塞型睡眠呼吸暂停综合征 + 彩色多普勒超声　；参考：《山西医科大学》2011年硕士论文

【摘要】：目的探讨彩色多普勒血流显像（CDFI）检测阻塞型睡眠呼吸暂停综合征（OSAS）患者眼底动脉血流的变化，，并与血氧饱和度（Spo2）作相关性分析。资料与方法按照呼吸低通气指数（AHI）将OSAS患者分成轻度组（AHI＜20，15例）和重度组（AHI≥20，15例）；选取年龄相近的20例作为对照组。应用CDFI分别测量眼动脉（OA）、视网膜中央动脉（CRA）及睫状后动脉（PCA）。检测指标：收缩期峰值血流速度（PSV）、舒张末血流速度（EDV）及阻力指数（RI）。其结果与正常组对照，并与OSAS患者的血氧饱和度（Spo2）作相关性分析。结果 1.OSAS组（轻、重度）的CRA血流速度（PSV、EDV）显著高于正常组（P0.01）； 2.OSAS重度组的PCA血流速度（PSV、EDV）显著高于正常组（P0.01）； 3.OSAS重度组的平均血氧饱和度与PCA（PSV、EDV）呈负相关（r=-0.973,P=0.000;r=-0.96,P=0.000）；与CRA、OA的血流参数无相关性。结论 OSAS患者眼底动脉血流存在显著改变。主要表现为重度组的PCA流速加快，血氧饱和度越低则眼底动脉流速越快。说明缺氧导致高碳酸血症，使血管扩张，血流速度加快。从而间接反映了患者全身中小动脉血管的病变，反映了导致动脉硬化之前血管功能的代偿阶段。应用CDFI检测OSAS患者眼底血流的这一变化具有重要的临床意义。
[Abstract]:Purpose To investigate the changes of fundus arterial blood flow in patients with obstructive sleep apnea syndrome (OSAS) by color Doppler flow imaging (CDFI), and to analyze the correlation between CDFI and oxygen saturation (SPO _ 2) in patients with obstructive sleep apnea syndrome (OSAS). Data and methods According to the respiratory hypopnea index (AHI), the patients with OSAS were divided into two groups: mild group (15 cases) and severe group (15 cases), and 20 cases of similar age were selected as control group. CDFI was used to measure the optic artery (CDFI), central retinal artery (CA) and posterior ciliary artery (PCA). Parameters: peak systolic velocity (PSV), end diastolic velocity (EDV) and resistance index (RI). The results were compared with those in normal control group and were correlated with oxygen saturation of OSAS patients (Spo2). Result The blood flow velocity of CRA in 1.OSAS group (light and severe) was significantly higher than that in normal group (P 0.01). The blood flow velocity of PCA in severe 2.OSAS group was significantly higher than that in normal group (P 0.01). The mean oxygen saturation in severe 3.OSAS group was negatively correlated with PSV EDV, but had no correlation with the blood flow parameters of 3.OSAS. Conclusion There were significant changes in fundus arterial blood flow in patients with OSAS. In the severe group, the PCA velocity was accelerated, and the lower the oxygen saturation was, the faster the velocity of the fundus artery was. Hypoxia leads to hypercapnia, vasodilation and faster blood flow. It indirectly reflects the lesion of arterioles and the compensatory stage of vascular function before arteriosclerosis. This change of fundus blood flow in patients with OSAS by CDFI has important clinical significance.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R766;R77

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