气道神经源性炎症在上气道咳嗽综合征中的作用

发布时间：2018-05-13 23:31

本文选题：上气道咳嗽综合征 + 慢性咳嗽　；参考：《实用医学杂志》2015年09期

【摘要】：目的:探讨上下气道神经源性炎症在上气道咳嗽综合征(UACS)发生机制中的作用。方法:募集UACS患者12例,并与无咳嗽的15例变应性鼻炎(AR)患者和10例健康志愿者进行比较。均行鼻腔灌洗炎症细胞计数和诱导痰炎症细胞分类检查,并检测鼻灌洗液及诱导痰上清液中P物质(SP)、神经肽A(NKA)、神经肽B(NKB)以及降钙素基因相关肽(CGRP)含量。结果 :UACS患者鼻灌洗液及诱导痰上清液中嗜酸粒细胞均较健康志愿者增高(P0.01),但低于单纯AR患者。UACS患者鼻灌洗、诱导痰上清液中SP、CGRP含量均高于健康志愿者(P0.01),且SP也高于AR患者(P0.05)。NKA、NKB的比较:除UACS患者鼻灌洗液中NKA高于其他两组外(P0.01),余组间比较差异均无统计学意义(P0.05)。结论:感觉神经肽导致的气道神经源性炎症参与了UACS的发病,可能是UACS引起咳嗽的机制之一。
[Abstract]:Objective: to investigate the role of neurogenic inflammation of upper and lower airway in the pathogenesis of upper airway cough syndrome (UACSs). Methods: twelve patients with UACS were recruited and compared with 15 patients with allergic rhinitis without cough and 10 healthy volunteers. The count of inflammatory cells in nasal cavity lavage and the classification of induced sputum inflammatory cells were examined. The contents of substance P (SP), neuropeptide Agna NKAO, neuropeptide BnkB (NPB) and calcitonin gene-related peptide (CGRP) in nasal lavage fluid and supernatant of induced sputum were detected. Results the eosinophils in the nasal lavage fluid and the supernatant of induced sputum in the patients with 1% UACS were higher than those in the healthy volunteers (P 0.01), but lower than those in the patients with AR and UACS alone. The content of SPN CGRP in supernatant of induced sputum was higher than that in healthy volunteers (P 0.01), and SP was higher than that in AR patients (P 0.05). The NKA in nasal lavage fluid of patients with UACS was higher than that of other two groups (P 0.01), but there was no significant difference between the other groups (P 0.05). Conclusion: airway neurogenic inflammation induced by sensory neuropeptide may be involved in the pathogenesis of UACS and may be one of the mechanisms of cough induced by UACS.
【作者单位】：南京军区南京总医院耳鼻咽喉头颈外科;
【基金】：南京军区南京总医院院管课题(编号:2011010)
【分类号】：R765

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