COX-2蛋白在鼻咽癌中的表达及其临床意义

发布时间：2018-05-14 16:18

本文选题：COX-蛋白 + 鼻咽癌　；参考：《山东大学耳鼻喉眼学报》2009年06期

【摘要】：目的探讨COX-2(cyclooxygenase-2)蛋白在鼻咽癌组织中的表达及其临床意义。方法分别应用免疫组化方法(IHC)和蛋白印迹方法(Western Blot)检测47例鼻咽癌组织(其中用IHC33例,Western Blot14例)及24例鼻咽部炎症组织中COX-2蛋白的表达。结果COX-2蛋白在鼻咽癌组织的阳性表达率为81.8%(27/33),在鼻咽炎组织的阳性表达率为25%(3/12),两者表达差异有统计学意义(P=0.001)。Western Blot结果显示,在两种组织中COX-2蛋白表达的相对值分别为1.258±0.034和0.487±0.076,在鼻咽癌组表达显著增高(P=0.000)。结论COX-2蛋白的高度表达在鼻咽癌的发生、发展中起重要作用,选择性COX-2抑制剂有望成为鼻咽癌化疗的重要药物。
[Abstract]:Objective to investigate the expression of cyclooxygenase-2 (COX-2) protein in nasopharyngeal carcinoma (NPC) and its clinical significance. Methods the expression of COX-2 protein in 47 cases of nasopharyngeal carcinoma (including IHC33) and 24 cases of nasopharyngeal inflammation were detected by immunohistochemistry and Western blot. Results the positive expression rate of COX-2 protein in nasopharyngeal carcinoma was 81.80.27 / 33, and that in nasopharyngitis tissue was 25 / 12. The difference between them was statistically significant. The results of Western Blot showed that the expression of COX-2 protein in nasopharyngeal carcinoma was significantly higher than that in nasopharyngeal carcinoma (P < 0.05). The relative values of COX-2 protein expression were 1.258 卤0.034 and 0.487 卤0.076, respectively. The expression of COX-2 protein in nasopharyngeal carcinoma was significantly higher than that in nasopharyngeal carcinoma group (1.258 卤0.034 and 0.487 卤0.076, respectively). Conclusion the high expression of COX-2 protein plays an important role in the pathogenesis and development of nasopharyngeal carcinoma. Selective COX-2 inhibitors are expected to be important drugs for nasopharyngeal carcinoma chemotherapy.
【作者单位】：南华大学附属第二医院耳鼻咽喉科;南华大学肿瘤研究所;浙江大学附属第二医院眼科;
【分类号】：R739.63

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