粉尘螨滴剂治疗不同年龄变应性鼻炎患者的疗效评估

发布时间：2018-05-15 10:38

本文选题：舌下特异性免疫治疗 + 鼻炎　；参考：《临床耳鼻咽喉头颈外科杂志》2014年05期

【摘要】：目的:探讨标准化粉尘螨滴剂个体化舌下特异性免疫治疗(SLIT)不同年龄变应性鼻炎(AR)患者的疗效。方法:以150例对粉尘螨过敏的AR患者为研究对象,均以标准化粉尘螨滴剂进行1.5~2.0年的SLIT,期间联合对症药物治疗。按就诊年龄将患者分为5组:第1组(5~7岁,17例),第2组(7~12岁,38例),第3组(12~18岁,31例),第4组(19~40岁,38例)和第5组(40岁,26例)。评估不同年龄组患者的鼻部症状评分(TNSS)、体征评分和药物评分(TMS)的变化。对于其中SLIT不稳定或不理想的AR患者进行个体化剂量调整。结果:与治疗前相比,SLIT 0.5、1.0、1.5~2.0年后,不同年龄组AR患者的TNSS、TMS以及体征评分均显著改善(均P0.05);TNSS、体征评分以及TMS组间均差异无统计学意义(均P0.05)。结论:采用标准化粉尘螨滴剂对不同年龄AR患者进行1.5~2.0年个体化SLIT均有疗效;不同年龄组患者取得的总体疗效未见明显差别。
[Abstract]:Objective: to investigate the efficacy of sublingual specific immunotherapy for patients with allergic rhinitis at different ages. Methods: 150 AR patients who were allergic to Dermatophagoides farinae were treated with standardized dust mites drops for 1.5 ~ 2.0 years. The patients were divided into 5 groups according to their age: group 1 (17 cases), group 2 (37 cases), group 2 (38 cases), group 3 (1218 years) 31 cases, group 4 (19 40 years old, 38 cases) and group 5 (26 cases). To evaluate the changes of nasal symptom score (TNSS), sign score and drug score (MS) in patients with different age groups. Individual dose adjustment was performed in AR patients with unstable or unsatisfactory SLIT. Results: compared with before treatment, the TMS and sign scores of AR patients in different age groups were significantly improved (P 0.05). There was no significant difference in the scores of signs and signs between the two groups (all P 0.05). Conclusion: standardized Dermatophagoides farinae drops are effective for 1.5 ~ 2.0 years of individualized SLIT in AR patients of different ages, but there is no significant difference in the overall efficacy among different age groups.
【作者单位】：九江学院附属医院耳鼻咽喉-头颈外科;
【分类号】：R765.21

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