耳鸣患者静息态MR的局部区域一致性研究

发布时间：2018-05-17 13:26

本文选题：耳鸣严重程度 + THI　；参考：《中华耳科学杂志》2014年02期

【摘要】：目的研究耳鸣患者静息态fMRI的区域一致性(regional homogeneity,Reho)值脑区功能及中枢网络连接特点,从神经影像学及功能连接方面进一步阐明耳鸣的中枢发病机制。方法对18例耳鸣患者与20例年龄、性别相匹配的健康人群的分别行静息态功能性核磁共振(fMRI)检查,分析比较其Reho值变化,再将异常脑区或听觉中枢做为种子点行功能网络连接,研究耳鸣患者的脑区及功能网络连接变化。结果 ReHo表现为耳鸣组正常组的脑区有双侧额下回、右侧颞中回、双侧中央后回;耳鸣组正常组的脑区有小脑半球。经FWE严格校正后耳鸣组比对照组增强的区域为额下回(FWE P0.05)减弱的区域为小脑前叶(FWE P0.05,cluster level)。以额下回IFG作为种子点行功能连接,发现对照组耳鸣组的区域为中脑(FWE,P0.001)及右腹侧纹状体(FWE P0.05,Small volume correction)。结论耳鸣的fMRI结果显示耳鸣患者的听觉中枢及非听觉中枢均在耳鸣中起重要作用,中枢功能连接提示耳鸣患者听觉脑区丘脑、颞中回与边缘系统海马旁回、岛叶等存在功能连接是导致耳鸣发生发展的原因之一。
[Abstract]:Objective to study the regional consistency of regional homogenity fMRI in tinnitus patients and the characteristics of central network connection, and to further elucidate the central pathogenesis of tinnitus from the aspects of neuroimaging and functional connection. Methods 18 patients with tinnitus and 20 healthy subjects matched by age and sex were examined by resting functional magnetic resonance imaging (fMRI). The changes of Reho were analyzed and compared. The abnormal brain area or auditory center were used as seed points to connect the functional network. To study the changes of brain area and functional network connection in tinnitus patients. Results ReHo showed bilateral inferior frontal gyrus, right middle temporal gyrus, bilateral posterior central gyrus in normal tinnitus group, and cerebellar hemisphere in normal tinnitus group. After strict correction by FWE, the area of enhancement in tinnitus group was FWE P0.05 in inferior frontal gyrus (FWE P0.05), and the area weakened by FWE P0.05 cluster level in anterior lobe of cerebellum. Using IFG in subfrontal gyrus as seed point, functional junctions were performed. It was found that the regions of the tinnitus group in the control group were FWEP0.001) and FWE P0.05 small volume correction in the right ventral striatum. Conclusion the fMRI results of tinnitus show that the auditory and non-auditory centers of tinnitus play an important role in tinnitus. The central functional connections suggest that the thalamus, the middle temporal gyrus and the perihippocampal gyrus of the marginal system play an important role in tinnitus patients with tinnitus. The existence of functional connections in insular leaves is one of the reasons leading to the development of tinnitus.
【作者单位】：中山大学孙逸仙纪念医院耳鼻咽喉头颈外科;
【基金】：国家自然科学基金(81170921) 广东省自然科学基金(S2011010004576)
【分类号】：R764.45

【共引文献】