伊曲康唑治疗真菌性角膜炎的临床效果研究

发布时间：2018-05-20 00:32

本文选题：伊曲康唑 + 两性霉素B　；参考：《中华医院感染学杂志》2015年04期

【摘要】：目的研究伊曲康唑治疗真菌性角膜炎临床效果,为合理用药提供参考依据。方法选择2011年3月-2014年2月收治的36例真菌性角膜炎患者为观察组,采用伊曲康唑+两性霉素B+氟康唑滴眼液治疗,回顾性调查2005年3月-2011年3月收治的36例真菌性角膜炎患者临床资料为对照组,给予两性霉素B+氟康唑滴眼液治疗,连续治疗1个月后对两组治疗效果进行评估并记录。结果治疗有效率观察组为97.2%、对照组为88.9%,治疗有效率观察组高于对照组,差异有统计学意义(P0.05);观察组患者的角膜溃疡、前房积脓、畏光流泪恢复时间均明显短于对照组,差异有统计学意义(P0.05);两组患者在治疗过程中均无明显不良反应发生。结论在两性霉素B和氟康唑的基础上加用伊曲康唑治疗真菌性角膜炎效果,优于仅应用两性霉素B和氟康唑,且可缩短治疗所需时间,治疗安全性较好,值得临床推广。
[Abstract]:Objective to study the clinical effect of itraconazole in the treatment of fungal keratitis and to provide reference for rational use of itraconazole. Methods from March 2011 to February 2014, 36 patients with fungal keratitis were treated with itraconazole amphotericin B fluconazole eye drops. The clinical data of 36 patients with fungal keratitis from March 2005 to March 2011 were retrospectively investigated. The control group was treated with amphotericin B fluconazole eye drops. The therapeutic effects of the two groups were evaluated and recorded after one month of continuous treatment. Results the effective rate of treatment was 97.2g in the observation group and 88.9in the control group. The effective rate of treatment in the observation group was higher than that in the control group, the difference was statistically significant (P 0.05), and the recovery time of corneal ulcer, anterior chamber pus and photophobia in the observation group was significantly shorter than that in the control group. The difference was statistically significant (P 0.05), and there were no significant adverse reactions in both groups. Conclusion on the basis of amphotericin B and fluconazole, itraconazole is better than amphotericin B and fluconazole in treating fungal keratitis.
【作者单位】：江山市中医院眼科;
【基金】：江山市科技局基金资助项目(2013F05)
【分类号】：R772.21

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