鼻咽癌调强放射治疗中原发肿瘤容积与预后关系的初步研究

发布时间：2018-05-20 03:23

  本文选题：鼻咽癌 + 调强　； 参考：《泸州医学院》2011年硕士论文

【摘要】：目的：放射治疗是鼻咽癌首选的治疗手段。在恶性肿瘤的放射治疗中,原发肿瘤容积作为预后因素之一,正越来越受到临床医生的关注。本研究通过对鼻咽癌患者原发肿瘤容积的研究,初步探讨鼻咽癌患者的原发肿瘤容积与临床不同治疗模式的关系及其预后的意义,为更加合理的治疗鼻咽癌提供临床依据。 材料和方法：本研究对接受新辅助化疗加同期放化疗(CCRT)或同期放化疗的鼻咽癌患者进行了一项回顾性分析研究,以研究鼻咽癌原发灶大小对治疗结果的影响,回顾性分析了68例接受调强放射治疗的晚期鼻咽癌患者(Ⅲ-Ⅳ期)的资料,所有患者鼻咽病理均为低分化鳞癌.原发灶根据鼻咽癌2002 UICC分期,T2-T4期患者数分别为14、27和27例。接受新辅助化疗加同期放化疗放疗患者为20例(占29.4%),接受同期放化疗患者为48(占70.6%),鼻咽部病灶照射剂量为69-75Gy,30-33分次,6-7周。放疗前的CT/MRI融合图像在NOMOS公司CORVUS逆向计划系统直接逐层勾画肿瘤边缘在相应CT图像中,利用放疗计划系统自动计算出比较精确的肿瘤容积,原发灶的区域GTV包括原发肿瘤和咽后侵犯的淋巴结。结果：全组患者的原发肿瘤容积大小,其范围为(11.94-108.00)cm3,中位数为57.63cm3,平均数为60.83cm3。将50cm3作为全组患者原发肿瘤容积的临界点,将其分
[Abstract]:Objective: radiotherapy is the first choice for nasopharyngeal carcinoma. Primary tumor volume, as a prognostic factor, has attracted more and more attention of clinicians in radiotherapy of malignant tumors. Through the study of primary tumor volume in patients with nasopharyngeal carcinoma (NPC), the relationship between primary tumor volume and different clinical treatment modes and its prognostic significance were preliminarily discussed in order to provide a more reasonable clinical basis for the treatment of nasopharyngeal carcinoma (NPC). Materials and methods: a retrospective study was conducted in patients with nasopharyngeal carcinoma (NPC) receiving neoadjuvant chemotherapy plus concurrent radiotherapy and chemotherapy (CCRTT) or concurrent radiotherapy and chemotherapy to study the effect of primary tumor size on the outcome of treatment. The data of 68 patients with advanced nasopharyngeal carcinoma (stage 鈪，

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