TNFAIP3、Mn-SOD在放射治疗鼻咽癌中的意义

发布时间：2018-05-20 11:37

  本文选题：TNFAIP基因 + Mn-SOD基因　； 参考：《南京医科大学学报(自然科学版)》2014年11期

【摘要】：目的 :研究肿瘤坏死因子α诱导蛋白3(tumor necrosis factor alpha induced protein 3,TNFAIP3)、锰超氧化物歧化酶(Manganese superoxide dismutase,Mn-SOD)m RNA在放射治疗后鼻咽癌中的表达,探讨其在鼻咽癌放射治疗中的意义。方法 :运用原位杂交方法检测放射治疗后鼻咽癌中TNFAIP3及Mn-SOD m RNA的表达。结果:TNFAIP3 m RNA中度及强阳性表达率在放疗敏感鼻咽癌中为15.00%,在放疗抗拒鼻咽癌中为45.00%;Mn-SOD m RNA中度及强阳性表达率在放疗敏感鼻咽癌中为55.00%,在放疗抗拒鼻咽癌中为40.00%,差异均有统计学意义(P均0.05)。在放疗抗拒鼻咽癌中,TNFAIP3 m RNA中度及强阳性表达率与TNM分期呈正相关,Ⅲ~Ⅳ期表达率为48.28%,Ⅰ~Ⅱ期表达率为36.36%,Mn-SOD m RNA中度及强阳性表达率与T分期呈正相关,T3~T4期中表达率为63.16%,T1~T2期中表达率为19.05%;TNFAIP3 m RNA中度及强阳性表达率在有远处转移的放疗抗拒鼻咽癌中为81.81%,在无远处转移的放疗抗拒鼻咽癌中为31.03%,Mn-SOD m RNA中度及强阳性表达率在有远处转移的放疗抗拒鼻咽癌中为81.82%,在无远处转移的放疗抗拒鼻咽癌中为24.14%,差异均有统计学意义(P均0.05)。结论:TNFAIP3参与了放疗抗拒鼻咽癌的发生、发展;Mn-SOD能增加鼻咽癌的放射敏感性,增强放疗鼻咽癌的抗氧化作用。
[Abstract]:Objective: to study the expression of tumor necrosis factor 伪 -inducible protein 3(tumor necrosis factor alpha induced protein _ 3 (TNFAIP _ 3) and Manganese superoxide dismutase (Mn-SODm) RNA in nasopharyngeal carcinoma (NPC) after radiotherapy, and to explore its significance in radiotherapy of nasopharyngeal carcinoma (NPC). Methods: the expression of TNFAIP3 and Mn-SOD m RNA in nasopharyngeal carcinoma after radiotherapy was detected by in situ hybridization. Results the positive rates of moderate and strong expression of RNA of 10% TNFAIP3 m were 15.00 in radiotherapy sensitive nasopharyngeal carcinoma, 45.00% in radiotherapy resistant nasopharyngeal carcinoma, 55.00% in radiotherapy sensitive nasopharyngeal carcinoma, 40.005% in radiotherapy resistant nasopharyngeal carcinoma, 45.00% in radiotherapy resistant nasopharyngeal carcinoma. The difference was statistically significant (P < 0.05). The positive expression rate of TNFAIP3 m RNA in radiotherapy resistant nasopharyngeal carcinoma was positively correlated with TNM stage. The expression rate of Mn-sod m RNA in stage 鈪，

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