人乳头瘤病毒感染与口咽癌研究进展

发布时间：2018-05-21 00:10

本文选题：口咽肿瘤 + 人乳头瘤病毒　；参考：《中华肿瘤防治杂志》2014年06期

【摘要】：目的:总结人乳头瘤病毒(human papillomavirus,HPV)感染与口咽上皮的癌变机制和疗效预后的研究进展。方法:应用Medline和PubMed数据库检索系统,以"HPV、口咽癌"等为关键词,检索1998-01-2012-06相关文献,纳入标准:1)HPV生物学特性;2)HPV的致癌机制和传播途径;3)口咽癌中HPV感染率;4)HPV感染与口咽癌预后;5)HPV疫苗。根据纳入标准,符合分析的文献38篇。结果:HPV主要通过口-生殖器直接接触感染口腔黏膜,口咽癌组织中HPV感染率高于正常人群口腔黏膜上皮。PCR为基础的检测方式灵敏度最高、应用最为广泛,常见的检出型别是高危型HPV16/18。HPV阳性的口咽癌是一个独立的亚型,有独特的分子生物学和临床特点,肿瘤组织中p53突变少见,患者对放化疗敏感,长期预后好。HPV疫苗对口咽癌的预防效果仍有待观察。结论:HPV感染是口咽癌的重要致病因素和独立预后因子。
[Abstract]:Objective: To summarize the carcinogenesis and prognosis of human papillomavirus (human papillomavirus, HPV) infection and oropharyngeal epithelium. Methods: Medline and PubMed database retrieval system were used to search for "HPV, oropharynx cancer" as key words, and 1998-01-2012-06 phase Guan Wenxian was retrieved, 1) HPV biological characteristics; 2) the carcinogenic mechanism of HPV. 3) HPV infection rate in oropharyngeal carcinoma; 4) HPV infection and oropharyngeal cancer prognosis; 5) HPV vaccine. According to the inclusion criteria, 38 articles in accordance with the analysis. Results: HPV is mainly infected with oral mucosa through oral genital organs, and the rate of HPV infection in oropharyngeal carcinoma is higher than that of normal human oral mucosa epithelium.PCR. The highest, most widely used, common detection type is a high risk type HPV16/18.HPV positive oropharyngeal carcinoma is an independent subtype, with unique molecular biology and clinical characteristics, p53 mutation in tumor tissue is rare, patients are sensitive to radiotherapy and chemotherapy, and the long-term prognosis of.HPV vaccine against oropharyngeal cancer is still to be observed. Conclusion: HPV sense Staining is an important pathogenic factor and independent prognostic factor of oropharyngeal carcinoma.
【作者单位】：解放军海军总医院基础医学研究中心;中国医学科学院肿瘤研究所·分子肿瘤学国家重点实验室;
【基金】：国家自然科学基金(91029725;30973373)
【分类号】：R739.6

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