重度OSAHS患者治疗前后MMP-9和FFA水平变化及意义

发布时间：2018-05-24 11:14

本文选题：睡眠呼吸暂停低通气综合征 + 基质金属蛋白酶P-9　；参考：《南华大学》2010年硕士论文

【摘要】： 目的对成人重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者治疗前后基质金属蛋白酶p-9(MMP-9)和游离脂肪酸(FFA)水平变化进行跟踪随访监测,从而探讨MMP-9及FFA与OSAHS患者呼吸紊乱指数、最低血氧饱和度及血脂相关性,为OSAHS病情程度及疗效评估提供相关的依据。方法对38例拥有完整病例并符合纳入条件的经PSG监测诊断为重度OSAHS患者,抽取清晨空腹血测试MMP-9、FFA、及临床常规血脂四项(TG、TC、HDL、LDL)。对患者进行手术(H-UPPP术)解除气道阻塞,并于术前一周给予CPAP治疗。对其治疗前和治疗后3个月相应指标做出比较。将所得数据进行SPSS16.0统计学软件处理分析并得出结论。结果 1.OSAHS患者经治疗后:LSaO2明显上升(P0.01),AHI明显下降(P0.01),有统计学意义。 2.OSAHS患者经治疗后:血清MMP-9值、FFA值显著下降(P0.01),有统计学意义。 3.OSAHS患者经治疗后:血脂四项中TG、TC、LDL值下降(P0.01),HDL值上升(P0.01),有统计学意义。 4 .MMP-9、FFA与AHI、LSaO2、TG、TC、HDL及LDL ,经逐步回归分析:AHI、LSaO2、TG与MMP-9、FFA关系最密切,对OSAHS患者体内MMP-9、FFA影响最明显( P0.01),有统计学意义。 5. MMP-9、FFA与AHI、LSaO2、TG、TC、HDL及LDL,经相关分析:FFA与AHI、TG成正相关( P0.01),与LSaO2、HDL成负相关( P0.05),有统计学意义;MMP-9与AHI、TG成正相关( P0.01),与LSaO2成负相关( P0.01),有统计学意义。MMP-9和FFA与TC、LDL成正相关( P0.05),无统计学意义。 6.MMP-9与FFA经直线回归分析:MMP-9与FFA成正相关( P0.01),有统计学意义。结论 1.有效的治疗OSAHS,可以降低MMP-9与FFA的水平。 2. MMP-9和FFA可以作为评估OSAHS患者病情严重程度的重要指标之一。
[Abstract]:Purpose The changes of matrix metalloproteinase p-9 (MMP-9) and free fatty acid (FFA) levels in adult patients with severe obstructive sleep apnea hypopnea syndrome (OSAHS) before and after treatment were followed up, and the respiratory disturbance index of patients with MMP-9, FFA and OSAHS were investigated. The correlation between minimum oxygen saturation and blood lipids may provide relevant evidence for the evaluation of the severity and curative effect of OSAHS. Method A total of 38 patients with severe OSAHS diagnosed by PSG monitoring were selected for early morning fasting blood samples for testing MMP-9 FFAs, and four items of routine blood lipids, TGG TCC and HDLL, were collected from 38 patients who were diagnosed as severe OSAHS by PSG monitoring. The airway obstruction was relieved by H-UPPP and CPAP was given one week before operation. The corresponding indexes before treatment and 3 months after treatment were compared. The data are processed and analyzed by SPSS16.0 statistical software and the conclusion is drawn. Result After the treatment of 1.OSAHS patients, the ratio of w / L SaO2 increased significantly (P 0.01) and decreased significantly (P 0.01). After treatment, the serum MMP-9 value and FFA value of 2.OSAHS patients decreased significantly (P 0.01). After treatment, there was a significant difference between the four items of serum lipids, the decrease of TGG TCU LDL value and the increase of HDL value (P 0.01 and P 0.01) in the patients with 3.OSAHS. 4. MMP-9 FFA was most closely related to TGG and LDL by stepwise regression analysis, and had the most significant effect on MMP-9 FFA in patients with OSAHS (P0.01, P 0.01, P < 0.05). 5. MMP-9 FFA was positively correlated with AHI LSAO 2 TGG TCU HDL and LDL. The positive correlation was found between FFA and TG (P0.01), and negative correlation was found with LSaO2 HDL (P0.05). There was a significant positive correlation between MMP-9 and LSaO2 (P0.01, MMP-9, FFA and TCLDL) (P0.05P, no statistical significance). 6.MMP-9 and FFA were positively correlated with FFA by linear regression analysis (P 0.01). Conclusion 1. Effective treatment of OSAHS can reduce the levels of MMP-9 and FFA. 2. MMP-9 and FFA can be used as an important index to evaluate the severity of OSAHS.
【学位授予单位】：南华大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R766

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