脑蛋白水解物与鼠神经生长因子对青光眼术后视神经的保护作用

发布时间：2018-05-24 12:58

本文选题：青光眼 + 脑蛋白水解物注射剂　；参考：《眼科新进展》2014年05期

【摘要】：目的比较脑蛋白水解物与鼠神经生长因子对原发性闭角型青光眼术后视神经的保护作用。方法选取2011年1月至2012年12月我院小梁切除术后原发性闭角型青光眼患者80例(80眼),随机分成脑蛋白水解物组与鼠神经生长因子组。脑蛋白水解物组给予脑蛋白水解物注射剂,鼠神经生长因子组给予注射用鼠神经生长因子,均连续治疗4周。比较两组治疗前及治疗后1个月的视力、眼压、视野、视觉诱发电位等。结果脑蛋白水解物组患者治疗前视力为0.38±0.40,治疗后1个月为0.51±0.38,治疗后显著高于治疗前,差异有统计学意义(P=0.040);鼠神经生长因子组治疗前视力为0.46±0.33,治疗后1个月为0.48±0.35,差异无统计学意义(P=0.552);脑蛋白水解物组治疗后视力显著高于鼠神经生长因子组,差异有统计学意义(P=0.046)。脑蛋白水解物组患者治疗后1个月的平均视敏度、P100波振幅显著高于治疗前(P=0.000、0.028),视野平均缺损值、P100波潜伏期显著低于治疗前(P=0.000、0.000);鼠神经生长因子组患者治疗后的平均视敏度、P100波振幅显著高于治疗前(P=0.021、0.045),P100波潜伏期显著低于治疗前(P=0.026)。脑蛋白水解物组治疗后的视力、平均视敏度、P100波振幅显著高于鼠神经生长因子组(P=0.046、0.003、0.012),视野平均缺损值、P100波潜伏期显著低于鼠神经生长因子组(P=0.036、0.032)。结论脑蛋白水解物注射液与注射用鼠神经生长因子均可稳定患者视力,改善视野,促进部分视神经功能的恢复,但脑蛋白水解物注射液作用明显优于注射用鼠神经生长因子。
[Abstract]:Objective to compare the protective effects of brain protein hydrolysate and nerve growth factor (NGF) on optic nerve after primary angle-closure glaucoma. Methods from January 2011 to December 2012, 80 patients with primary angle-closure glaucoma after trabeculectomy in our hospital were randomly divided into brain protein hydrolysate group and rat nerve growth factor group. The brain protein hydrolysate group was given the brain protein hydrolysate injection, and the rat nerve growth factor group was given the injection nerve growth factor for 4 weeks. Visual acuity, intraocular pressure, visual field and visual evoked potential were compared before and 1 month after treatment. Results the visual acuity was 0.38 卤0.40 before treatment and 0.51 卤0.38 at 1 month after treatment in the brain protein hydrolysate group, which was significantly higher than that before treatment. The visual acuity of nerve growth factor group was 0.46 卤0.33 before treatment and 0.48 卤0.35 one month after treatment. The visual acuity of brain protein hydrolysate group was significantly higher than that of nerve growth factor group after treatment, and the difference was statistically significant. The amplitude of P100 wave was significantly higher in the brain protein hydrolysate group than that in the pre-treatment group, and the latency of the P100 wave was significantly lower than that of the control group, and the mean visual acuity in the nerve growth factor group was significantly lower than that in the nerve growth factor group after treatment. The amplitudes of sensitivity P100 wave were significantly higher than that of P0. 021 and 0. 045 P100 wave latencies before treatment, which were significantly lower than that of P0. 026 before treatment. After treatment, the mean visual acuity P100 wave amplitude in the brain protein hydrolysate group was significantly higher than that in the nerve growth factor group, and the latency of P100 wave was significantly lower than that in the nerve growth factor group. Conclusion both brain protein hydrolysate injection and nerve growth factor for injection can stabilize visual acuity, improve visual field and promote partial recovery of optic nerve function, but the effect of brain protein hydrolysate injection is obviously better than that of injection rat nerve growth factor.
【作者单位】：柳州市中医院眼科;
【分类号】：R775.2

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