曲安奈德不同给药方式联合倍频532nm激光治疗视网膜静脉阻塞黄斑水肿的疗效比较

发布时间：2018-05-26 16:48

本文选题：曲安奈德 + 玻璃体腔注射　；参考：《武汉大学学报(医学版)》2014年05期

【摘要】：目的:比较曲安奈德(TA)通过后Tenon’s和玻璃体腔注射联合倍频532nm激光黄斑光凝治疗视网膜静脉阻塞性黄斑水肿的疗效。方法:经荧光素眼底血管造影和光学相干断层扫描检查确诊为视网膜静脉阻塞性黄斑水肿患者55例(55只眼),数字随机法分为曲安奈德玻璃体腔注射(IVTA)组25例(25只眼),后Tenon’s注射(PSTA)组30例(30只眼),分别行TA玻璃体腔注射和后Tenon’s注射,2-3周后再行注射治疗一次,两组均于第2次注药后2周行黄斑区局部或格栅样光凝,对比观察两组治疗前、治疗后1,3,6个月最佳矫正视力、眼压、黄斑厚度及并发症情况。结果:两组治疗前及治疗后1,3,6个月各时间点组内对比最佳矫正视力及黄斑中心厚度差异均有统计学意义(P0.05);两组间在1,3,6个月的最佳矫正视力、黄斑中心厚度的变化差异均无统计学意义(P0.05);两组平均眼压比较差异有统计学意义(P0.05)。结论:TA两种不同给药方式联合激光治疗均可减轻黄斑水肿,提高患者视力,均是治疗视网膜静脉阻塞黄斑水肿的有效方法,PSTA并发症少,在眼压升高方面具有更好的安全性和耐受性。
[Abstract]:Aim: to compare the therapeutic effects of triamcinolone acetonide (TAA) on retinal vein obstructive macular edema (RVO) with intravitreal injection and frequency doubling 532nm laser macular photocoagulation. Methods: 55 patients with retinal vein obstructive macular edema diagnosed by fundus fluorescein angiography and optical coherence tomography were randomly divided into 25 patients with intravitreal injection of triamcinolone acetonide and 25 patients with macular edema by intravitreal injection of triamcinolone acetonide. In the Tenon's injection group, 30 eyes were treated with TA intravitreal injection and 2 to 3 weeks after Tenon's injection respectively. The macular area local or grid photocoagulation was performed 2 weeks after the second injection in both groups. The best corrected visual acuity, intraocular pressure, macular thickness and complications were compared between the two groups before treatment, 1 and 6 months after treatment. Results: there were significant differences in the best corrected visual acuity (BCVA) and macular central thickness (BCVA) between the two groups before treatment and at 1 and 6 months after treatment (P 0.05), and the best corrected visual acuity (BCVA) between the two groups at 1: 3and 6 months after treatment was significantly higher than that in the control group (P < 0. 05). There was no significant difference in central macular thickness between the two groups (P 0.05), but there was significant difference in mean IOP between the two groups (P 0.05). Conclusion the combination of two different drug administration and laser therapy can reduce macular edema and improve the visual acuity of the patients. It is an effective method for the treatment of macular edema due to retinal vein occlusion. There are few complications of PSTA in the treatment of macular edema due to retinal vein occlusion. It has better safety and tolerance in increasing IOP.
【作者单位】：三峡大学仁和医院;
【分类号】：R774.1

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