角膜生物力学特性在近视眼患者中的改变及其影响因素

发布时间：2018-05-27 11:12

本文选题：眼反应分析仪 + 角膜滞后量　；参考：《汕头大学》2010年硕士论文

【摘要】：目的:测量角膜生物力学特性在近视眼患者中的改变及评估角膜生物力学特性与其他眼球生物学变量和年龄间的关系,并探测角膜生物力学特性在眼科的临床应用。对象与方法:采用眼反应分析仪测量99位成年近视眼患者(男59名,女40名,平均年龄23±4.1岁)任一眼的角膜滞后量(corneal hysteresis, CH)、角膜阻力因子量(corneal resistance factor, CRF)、角膜补偿性眼压值(cornea-compensated intraocular pressure, IOPcc)及Goldmann相关性眼压值(Goldmann-correlated intraocular pressure, IOPg),用角膜测厚仪测量中央角膜厚度(central corneal thickness, CCT),用IOL-Master测量眼轴,由全自动验光仪获取患者屈光度数及角膜曲率。应用单元及多元线性回归分析方法分析眼内压、年龄,中央角膜厚度、眼轴及角膜生物力学特性之间的关系。结果:角膜滞后量为9.74±1.37mmHg,角膜阻力因子量为9.55±1.54mmHg。在单元线性回归分析中,角膜滞后量和角膜阻力因子量与年龄、中央角膜厚度及IOPg之间存在相关关系(P值均0.05),而它们并不随角膜曲率的变化而变化(P值均0.05)。角膜滞后量还与眼轴,屈光度数间存在明显的相关关系(P0.05),相关系数分别为-0.262及0.222,而角膜阻力因子量与眼轴、屈光度数之间无明显相关关系(P0.05)。多元线性回归分析中,除外IOPg,角膜滞后量随着眼轴、CCT及年龄的变化而变化。而角膜阻力因子量仍然随着年龄、中央角膜厚度、IOPg的变化而变化。结论:角膜滞后量与角膜阻力因子量随着CCT的变薄和年龄的增加而降低。角膜滞后量随着眼轴的增长及近视度数的增加而下降,而角膜阻力因子量并不随着眼轴或近视度数的变化而变化。
[Abstract]:Objective: to measure the changes of corneal biomechanical properties in myopia patients and to evaluate the relationship between corneal biomechanical properties and other ocular biological variables and age, and to explore the clinical application of corneal biomechanical properties in ophthalmology. Participants and methods: 99 adult myopia patients (59 males, 40 females) were measured by eye response analyzer. Mean age (23 卤4.1 years) of corneal hysteresistics, chicks, corneal resistance factor, cornea-compensated intraocular pressure, IOPcc) and Goldmann associated intraocular pressure value Goldmann-correlated intraocular pressure, IOP, central corneal thickness, central corneal, etc. Thickness, CCT, IOL-Master measurement of eye axis, The diopter and corneal curvature were obtained by automatic optometry. The relationship between intraocular pressure (IOP), age, central corneal thickness, ocular axis and corneal biomechanical properties was analyzed by unit and multivariate linear regression analysis. Results: the corneal lag was 9.74 卤1.37 mm Hg and the corneal resistance factor was 9.55 卤1.54 mm Hg. In unit linear regression analysis, there was a correlation between corneal lag, corneal resistance factor and age, central corneal thickness and IOPg (P = 0.05), but they did not change with the change of corneal curvature (P = 0.05). There was also a significant correlation between corneal hysteresis and ocular axis and diopter, with correlation coefficients of -0.262 and 0.222, respectively. However, there was no significant correlation between corneal resistance factor and axial and diopter numbers (P 0.05). In multivariate linear regression analysis, except IOPg, corneal lag changed with the change of CCT and age. However, the corneal resistance factor still changes with age, central corneal thickness and IOPg. Conclusion: the amount of corneal lag and corneal resistance factor decrease with CCT thinning and age increasing. The corneal hysteresis decreased with the increase of the axis and the degree of myopia, but the corneal resistance factor did not change with the change of the axis or the degree of myopia.
【学位授予单位】：汕头大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R778.1

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