CD45RO在喉鳞状细胞癌中的表达及临床意义

发布时间：2018-05-31 06:45

本文选题：CDRO + 喉鳞状细胞癌　；参考：《临床耳鼻咽喉头颈外科杂志》2014年06期

【摘要】：目的:探讨喉鳞状细胞癌中CD45RO的表达及其临床意义,为喉鳞状细胞癌的预后评估提供新的思路,及为其生物治疗提供理论依据。方法:2010-01-2012-12期间我院确诊并手术治疗的初发喉鳞状细胞癌标本50例。另取10例喉部正常黏膜作对照分析。所有标本均经10%甲醛固定,石蜡包埋、切片。采用免疫组织化学、苏木精伊红染色方法检测CD45RO的阳性表达,分析其与喉鳞状细胞癌临床病理特征之间的关系。结果:CD45RO在正常组织及喉鳞状细胞癌中的阳性表达率分别为30%、86%。在50例喉癌病例中,CD45RO与局部淋巴结转移呈负相关(r=-0.713,P0.05),与肿瘤分区呈负相关(r=-0.750,P0.05),与年龄、T分类、病理分化程度、临床分期无明显相关性。结论:①CD45RO在喉鳞状细胞癌组织中的表达高于正常喉黏膜组织中的表达;②CD45RO过表达可能减少区域淋巴结转移;③CD45RO过表达可能有利于喉鳞状细胞癌患者的预后;④传统UICC-TNM分期、组织学分级评估预后不同,通过对CD45RO的检测可以从另外一个角度评估喉鳞状细胞癌的预后情况。
[Abstract]:Objective: to investigate the expression of CD45RO and its clinical significance in laryngeal squamous cell carcinoma (LSCC), and to provide a new method for prognosis evaluation of laryngeal squamous cell carcinoma (LSCC) and a theoretical basis for its biotherapy. Methods 50 cases of primary laryngeal squamous cell carcinoma (LSCC) diagnosed and surgically treated in our hospital from January to December 2012-12 were collected. Another 10 cases of normal laryngeal mucosa were taken as control analysis. All specimens were fixed with 10% formaldehyde, embedded in paraffin and sectioned. Immunohistochemistry and hematoxylin eosin staining were used to detect the positive expression of CD45RO and its relationship with the clinicopathological features of laryngeal squamous cell carcinoma (LSCC). Results the positive expression rates of CD45RO in normal tissue and laryngeal squamous cell carcinoma were 300.86%. In 50 cases of laryngeal carcinoma, CD45RO was negatively correlated with local lymph node metastasis, and negatively correlated with tumor subdivision. There was no significant correlation between CD45RO and age T classification, pathological differentiation and clinical stage. Conclusion the overexpression of CD45RO in laryngeal squamous cell carcinoma is higher than that in normal laryngeal mucosa. The overexpression of CD45RO may decrease the expression of CD45RO in regional lymph node metastasis, which may be beneficial to the prognosis of patients with laryngeal squamous cell carcinoma. (4) the prognosis of laryngeal squamous cell carcinoma can be evaluated by traditional UICC-TNM staging and histological grading. The prognosis of laryngeal squamous cell carcinoma can be evaluated from another angle by the detection of CD45RO.
【作者单位】：苏州大学附属第一医院耳鼻咽喉科;苏州大学附属第一医院病理科;
【基金】：江苏省苏州市国际技术引进与合作创新项目(No:SH201209) 江苏省苏州市科教兴卫青年科技项目(No:KJXW2012003)
【分类号】：R739.65

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