个体化口腔支架在鼻咽癌患者调强放疗中应用的剂量分析

发布时间：2018-06-01 08:44

本文选题：鼻咽癌 + 调强放疗　；参考：《中山大学学报(医学科学版)》2014年01期

【摘要】：【目的】在调强放疗(IMRT)中运用个体化口腔支架并通过剂量学分析,探索个体化口腔支架是否能有效减少鼻咽癌患者舌及口腔黏膜的照射体积及剂量,从而起到保护作用。【方法】将按入组条件收治的鼻咽癌患者随机分为试验组和对照组。临床上共收治初治鼻咽癌患者40例,其中试验组22例,对照组18例。两组患者均采用IMRT技术,试验组佩戴口腔支架,对照组不佩戴。两组患者均根据病情需要采用诱导、同期或辅助化疗,并酌情使用放射增敏剂。在保证处方剂量和优化目标一致的前提下进行剂量学分析,比较两组舌和口腔黏膜等所受的照射剂量和体积。【结果】调强剂量学分析表明两组患者靶区剂量适形度和均匀度无明显差异,而试验组舌、口腔黏膜及腮腺、脊髓等其他正常组织的受照剂量较对照组明显下降。【结论】鼻咽癌患者调强放疗中佩戴个体化口腔支架在不影响靶区剂量的前提下可减少口腔黏膜和舌的受照剂量和受照体积,及保护腮腺、下颌骨、中耳、脊髓等正常组织。
[Abstract]:[objective] to explore whether individualized oral stents can effectively reduce the volume and dose of tongue and oral mucosa in patients with nasopharyngeal carcinoma (NPC) by using individualized oral stents in IMRT. Methods Nasopharyngeal carcinoma patients were randomly divided into experimental group and control group. A total of 40 cases of nasopharyngeal carcinoma were treated clinically, including 22 cases in the experimental group and 18 cases in the control group. IMRT technique was used in both groups. Oral stents were used in the experimental group, but not in the control group. Both groups were treated with induction, concurrent or adjuvant chemotherapy according to their condition and radiosensitizer as appropriate. Dosimetry analysis is carried out on the premise that the prescription dose is consistent with the optimization goal. The dose and volume of tongue and oral mucosa were compared between the two groups. [results] intensity modulated dosimetry analysis showed that there was no significant difference in dose conformability and uniformity between the two groups, but in the test group, tongue, oral mucosa and parotid gland were not significantly different. The radiation dose of other normal tissues such as spinal cord was significantly lower than that of the control group. [conclusion] individualized oral stents can reduce the exposure of oral mucosa and tongue without affecting the dose of target area in patients with nasopharyngeal carcinoma by intensity modulated radiotherapy. Dose and exposure volume, And protection of parotid gland, mandible, middle ear, spinal cord and other normal tissue.
【作者单位】：暨南大学附属第一医院肿瘤科;中山大学附属肿瘤医院放疗科;
【基金】：广东省科技计划基金(2007B031505001)
【分类号】：R739.63

【相似文献】