117例中年OSAHS患者发病相关因素和治疗效果分析

发布时间：2018-06-04 00:45

本文选题：阻塞性睡眠呼吸暂停低通气综合征 + 发病因素　；参考：《第三军医大学学报》2014年05期

【摘要】：目的探讨中年阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypoventilation syndrome,OSAHS)患者发病的相关因素及其病理生理学参数和高危因素,并分析使用持续气道正压通气法(continuous positive airway pressure,CPAP)治疗后的效果。方法回顾性分析2010年6月至2012年6月第二军医大学长征医院和解放军第425医院耳鼻咽喉科住院收治的采用多导睡眠生理监测系统确诊并接受CPAP治疗的中年OSAHS患者117名[OSAHS组,年龄(51±6)岁]病例资料,并与30例"健康中年人"[对照组,年龄(53±4)岁]比较相关发病因素、高血压、高脂血症、肥胖、糖尿病和习惯性打鼾的罹患情况,根据两组的夜间心电图、脑电图、眼动图、下颌肌电图、下肢肌电图、血氧饱和度、鼾声等计算出OSAHS发病相关的参数,并对CPAP的治疗效果进行评价。结果①OSAHS组患者的体质量指数(body mass index,BMI)和有吸烟史的患者比例显著高于对照组(P0.05);②OSAHS组中患高血压、高脂血症、肥胖、糖尿病以及有习惯性打鼾的患者比例显著高于对照组(P0.05);③OSAHS组患者REM睡眠时长和最低SaO2、睡眠SaO2均低于对照组(P0.05),但呼吸暂停-低通气指数(apnea-hypopnea index,AHI)和腿动指数(leg movement index,LMI)均高于对照组(P0.05);④经CPAP治疗后,OSAHS患者的AHI、LMI、收缩压、最低SaO2、REM睡眠SaO2均有显著改善(P0.05)。结论 BMI增高和吸烟史是OSAHS发生的高危因素;高血压、高脂血症、肥胖、糖尿病和习惯性打鼾均与OSAHS的发病具有相关性;OSAHS患者睡眠功能紊乱,并导致患者严重缺氧。CPAP法可通过提高患者REM睡眠相的SaO2和最低SaO2来有效改善患者临床症状及发病的相关因素。
[Abstract]:Objective to explore the related factors, pathophysiological parameters and high risk factors of obstructive sleep apnea hypoventilation syndrome (OSAHS) in middle-aged patients with obstructive sleep apnea hypopnea syndrome (OSAHS), and to analyze the effect of continuous positive airway pressure ventilation (continuous positive airway pressure, CPAP) treatment. A retrospective analysis was made of 117 [OSAHS groups, aged (51 + 6) years of age (51 + 6) years of age (51 + 6), and 30 cases of "healthy middle-aged people" [the control group, age (53) (53) (53), who were admitted to the Department of Otolaryngology of the 425th Hospital of the Second Military Medical University from June 2010 to June 2012 and were admitted to the Department of otolaryngology. The incidence of related factors, hypertension, hyperlipidemia, obesity, diabetes and habitual snoring were compared. The parameters related to the OSAHS onset were calculated according to the night electrocardiogram, electroencephalogram, eye movement, mandibular electroencephalogram, lower extremity electromyogram, oxygen saturation, snoring and so on in the two groups, and the therapeutic effect of CPAP was evaluated. Results (1) OS The proportion of body mass index (body mass index, BMI) and smoking history in group AHS patients was significantly higher than that of the control group (P0.05); (2) the proportion of patients with hypertension, hyperlipidemia, obesity, diabetes and habitual snoring in the OSAHS group was significantly higher than that of the control group (P0.05); (3) the REM sleep length and the lowest SaO2 SaO2 in the OSAHS group were lower than those of the sleep SaO2. The control group (P0.05), but the apnea hypopnea index (apnea-hypopnea index, AHI) and the leg dynamic index (leg movement index, LMI) were all higher than those of the control group (P0.05); (4) after CPAP treatment, OSAHS patients were significantly improved. Hypertension, hyperlipidemia, obesity, diabetes and habitual snoring are associated with the incidence of OSAHS; the disorder of sleep in OSAHS patients and the cause of severe anoxia in patients with.CPAP can effectively improve the clinical symptoms and related factors of the patients by improving the SaO2 and the lowest SaO2 of the patients' REM sleep phase.
【作者单位】：解放军第425医院耳鼻咽喉科;第二军医大学长征医院耳鼻咽喉科;
【分类号】：R766

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