兰尼单抗治疗视网膜中央静脉阻塞黄斑水肿疗效的系统评价

发布时间：2018-06-06 04:33

本文选题：兰尼单抗 + 视网膜中央静脉阻塞黄斑水肿　；参考：《新疆医科大学》2011年硕士论文

【摘要】：目的系统评价0.3mg与0.5mg兰尼单抗治疗视网膜中央静脉阻塞黄斑水肿的疗效。方法按Cochrane系统评价方法,计算机检索MEDLINE(1966～2010.8)、EMbase (1980-2010.8)、Cochrane图书馆(2010年3期)和中国生物医学文献数据库(1979～2010.8),并手工检索相关会议文献。文献语种限制为中英文。收集所有相关随机对照试验,采用RevMan 5.0软件进行Meta分析。结果共纳入2篇随机对照试验,包括30例患者(共30只患眼)。Meta分析结果显示：与0.5mg兰尼单抗相比,0.3mg兰尼单抗在提高视网膜中央静脉阻塞黄斑水肿患者视力方面作用无差别[WMD=0.92,95%CI(-10.61,12.45)],在减轻患者黄斑水肿方面0.3mg兰尼单抗效果优于0.5mg, [WMD=120.49,95%CI (22.71,218.28)].。结论与0.5mg兰尼单抗相比,0.3mg兰尼单抗在提高视网膜中央静脉阻塞黄斑水肿患者视力方面无差异,在减轻黄斑水肿方面0.3mg效果优于0.5mg。但是两种剂量的药代动力学机制及远期效果尚待进一步研究。因本系统评价纳入研究病例数较少,上述结论需更多设计严谨大样本随机对照试验加以验证。
[Abstract]:Objective to evaluate the efficacy of 0.3mg and 0.5mg Lannimab in the treatment of macular edema due to central retinal vein occlusion. Methods according to the evaluation method of Cochrane system, MEDLINE (1966 / 2010.8) was searched by computer. The library of Cochrane (issue 3, 2010) and the Chinese Biomedical Literature Database (China) were searched by computer, and the related conference documents were searched manually. The language of the literature is restricted to Chinese and English. All the related randomized controlled trials were collected and Meta analysis was carried out with RevMan 5.0 software. Results two randomized controlled trials were conducted. A meta-analysis of 30 patients (30 eyes) showed that 0.3mg Lannimab had no difference in improving the visual acuity of patients with macular edema due to central retinal vein occlusion compared with 0.5mg Lannimab [WMD0.9295CI-10.61v12.45], but it could alleviate macular edema in patients with macular edema. The effect of 0.3mg Lanni monoclonal antibody was better than 0.5 mg, [WMDX 120.49 + 95 CI 22.71218.28]. Conclusion there is no difference in the visual acuity of patients with macular edema caused by central retinal vein occlusion compared with 0.5mg Lannimab, and the effect of 0.3mg in reducing macular edema is better than 0.5 mg. However, the pharmacokinetic mechanism and long-term effects of the two doses need to be further studied. Due to the small number of cases included in this systematic evaluation, the above conclusions need to be verified by more well-designed randomized controlled trials with large samples.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R774.1

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