广东省横沥镇葡萄膜炎流行病学调查

发布时间：2018-06-06 16:35

本文选题：葡萄膜炎 + 流行病学　；参考：《重庆医科大学》2013年博士论文

【摘要】：目的：评估广东省东莞市横沥镇40岁及以上人口葡萄膜炎的患病率,流行病学特点及危险因素。方法：于2011年7月至2011年12月应用人口基础横断面普查的方法对广东省东莞市横沥镇40岁及以上人口开展现场问卷调查及综合眼科检查。每位参与者均由专门培训的眼科医生详细问诊和综合眼科检查并详细记录,葡萄膜炎由2名葡萄膜炎专科医生和1名眼底病专科医生讨论后根据病史症状体征确诊。根据中国2010年第六次人口普查数据计算实际患病率与人口标准化患病率。分析葡萄膜炎流行病学特征及致盲危险因素。结果：东莞市横沥镇13个社区或村40岁及以上人口共11181人,实际参加调查8952人(男3594人,40.1%女5358人,59.9%)接受综合眼科检查。最终确诊81例葡萄膜炎(男44人,54.3%,女37人,45.7%)平均年龄为55.3±11.4岁。葡萄膜炎初始患病率和人口标准化患病率分别为905/100000人,882/100000人。在该年龄层男性患病率较女性高。44.7%的葡萄膜炎患眼最佳矫正视力达到低视力与盲,其中26.3%达到法定盲。其中内源性葡萄膜炎66人(81.5%),初始患病率和人口标准化患病率分别737/100000人和715/100000人。外伤性葡萄膜炎10人(12.3%),人口患病率为112/100000人,年龄标准化患病率为112/100000人。手术相关性葡萄膜炎5人(6.2%),人口患病率为56/100000人,年龄标准化患病率为56/100000人。其中37.1%的内源性葡萄膜炎患眼最佳矫正视力达到低视力与盲；90.0%的外伤性葡萄膜炎患眼最佳矫正视力达到低视力与盲；85.7%的手术相关性葡萄膜炎患眼最佳矫正视力达到低视力与盲。感染性葡萄膜炎15人(18.5%),人口患病率为168/100000人,年龄标准化患病率为168/100000人,其中外伤引起的感染性眼内炎占到感染性病因的60%；非感染性葡萄膜炎66人(81.5%),人口患病率为737/100000人,年龄标准化患病率为715/100000人。其中70.6%的感染性葡萄膜炎患眼最佳矫正视力达到低视力与盲；40.2%的非感染性葡萄膜炎患眼最佳矫正视力达到低视力与盲。特发性葡萄膜炎49人(60.5%),人口患病率为547/100000人,年龄标准化患病率为525/100000人。非特发性葡萄膜炎32人(39.5%),人口患病率为357/100000人,年龄标准化患病率为357/100000人。其中36.2%的特发性葡萄膜炎患眼最佳矫正视力达到低视力与盲；57.8%的非特发性葡萄膜炎患眼最佳矫正视力达到低视力与盲。前葡萄膜炎39人(48.2%),人口患病率为436/100000人,年龄标准化患病率为424/100000人。后葡萄膜炎23人(28.4%),人口患病率为257/100000人,年龄标准化患病率为257/100000人。全葡萄膜炎19人(23.5%),人口患病率212/100000人,年龄标准化患病率201/100000人。进一步病因分类,特发性虹膜睫状体炎(25,30.9%)为前葡萄膜炎7种病因类型中的主要类型；特发性后葡萄膜炎(21,25.9%)为后葡萄膜炎3种类型中的主要类型；而外伤性全葡萄膜炎(8,9.9%)和VKH综合征(4,4.9%)为6种全葡萄膜炎类型中的主要类型。本次调查未发现中间葡萄膜炎。其中25.9%的前葡萄膜炎患眼最佳矫正视力达到低视力与盲；55.9%的后葡萄膜炎患眼最佳矫正视力达到低视力与盲；69.2%的全葡萄膜炎患眼最佳矫正视力达到低视力与盲。结论：估计广东省东莞市横沥镇葡萄膜炎初始患病率和全国人口标准化患病率分别为905/100000人,882/100000人。估计广东省东莞市横沥镇每111人中有1人患葡萄膜炎,全国约113人有1人患葡萄膜炎,其中包括485人中一人的手术相关葡萄膜炎或外伤性葡萄膜炎。外伤性葡萄膜炎和感染性眼内炎是引起严重视力损伤的主要致病因素。
[Abstract]:Objective : To assess the prevalence , epidemiological characteristics and risk factors of the population in Hengli Town , Dongguan , Guangdong Province , from July 2011 to December 2011 .
90 . 0 % of patients with traumatic uveal tract had the best corrected visual acuity and blindness ;
85 . 7 % of the patients had low vision and blindness with the best corrected visual acuity . There were 15 ( 18.5 % ) cases of infective endocarditis , 168 / 100000 in the population , 168 / 100000 in the standardized prevalence of age , and 60 % of the infectious diseases caused by trauma .
Sixty - six ( 81.5 % ) patients with non - infective endocarditis ( 81.5 % ) had a population prevalence of 737 / 100000 , and the prevalence of age standardization was 715 / 100000 . Among them , 70.6 % of them had the best corrected visual acuity with low vision and blindness .
40 . 2 % of patients with non - infective endocarditis had the best corrected visual acuity and blindness . The prevalence rate was 55.2 % , and the prevalence rate was 357 / 100000 . The prevalence rate was 357 / 100000 . Among them , 36 . 2 % of patients with idiopathic diveitis had the best corrected visual acuity and blindness .
The age - standardized prevalence rate was estimated to be 257.2 % . The prevalence rate was 436 / 100000 . The prevalence of age standardization was 424 / 100000 . The prevalence of age was 257 / 100000 . The prevalence rate was 212 / 100000 . The age - standardized prevalence rate was 201 / 100000 . Further , the classification of etiologies , idiopathic iridotis ( 25 , 30.9 % ) were the main types of the seven types of etiologies of the former .
The main types of posterior diveitis ( 21 , 25 . 9 % ) were the main types of posterior diveitis .
In this study , the best corrected visual acuity was found to reach low vision and blindness .
In 55.9 % of the patients , the best corrected visual acuity of the eye reached low vision and blindness .
Conclusion : It is estimated that the initial prevalence rate and the prevalence rate of population standardization in Hengli Town of Dongguan City are 905 / 100000 and 882 / 100000 respectively .
【学位授予单位】：重庆医科大学
【学位级别】：博士
【学位授予年份】：2013
【分类号】：R773.9

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