质子泵抑制剂与促胃肠动力药治疗咽喉反流的Meta分析

发布时间：2018-06-13 02:32

本文选题：质子泵抑制剂 + 促胃肠动力药　；参考：《听力学及言语疾病杂志》2014年01期

【摘要】：目的评价质子泵抑制剂联合促胃肠动力药治疗咽喉反流的疗效和安全性。方法根据预定的纳入、排除标准,在cochrane图书馆、Embase、Elsevier、Pubmed、维普数据库(VIP)、万方数据库、中国知网(CNKI)和中国生物医学文献数据库(CBM)等中英文数据库中对应用质子泵抑制剂与促胃肠动力药治疗咽喉反流的文献进行检索,检索时限均为从建库至2012年11月。由三名评价员独立提取资料,应用Meta分析软件包Revman 5.1和GRAEDprofiler3.6对纳入的文献进行统计分析。结果共检索相关文献346篇,最终共纳入7篇符合纳入标准的文献,共614例患者,试验组及对照组各307例,试验组治疗方案为质子泵抑制剂和促胃肠动力药联合治疗,对照组为单用其中一种药。Meta分析结果显示:质子泵抑制剂和促胃肠动力药联合治疗咽喉反流患者的总体有效率高于对照组[RR=1.18,95%CI(1.10,1.28),P0.0001];纤维喉镜检查咽喉部体征好转率高于对照组[RR=1.38,95%CI(1.16,1.65),P0.001];发声障碍症状平均消失时间短于对照组[MD=-1.70,95%CI(-2.95,-0.45),P0.001]。结论质子泵抑制剂联合促胃肠动力药较分别单用这两类药治疗咽喉反流的疗效更显著,但就安全性而言,尚需更多的大样本、多中心、方法科学的高质量随机对照实验来进一步论证。
[Abstract]:Objective to evaluate the efficacy and safety of proton pump inhibitors combined with gastrointestinal motility drugs in the treatment of throat reflux. Methods according to the scheduled inclusion and exclusion criteria, the Embase Elsevier Pubmed, Weip database, Wanfang database were collected in the cochrane Library. Chinese and English databases such as CNKI and CBM were used to search the literature on the application of proton pump inhibitors and gastrointestinal motility drugs in the treatment of pharynx and larynx reflux. The searching time was from the establishment of the database to November 2012. The data were extracted by three evaluators and the data were analyzed by Meta-analysis software package Revman 5.1 and GRAEDprofiler 3.6. Results A total of 346 articles were retrieved, and 7 articles were included. A total of 614 patients, 307 patients in the experimental group and 307 in the control group were included in the study group. Proton pump inhibitor and gastrointestinal motility drugs were used as the treatment regimen in the experimental group. The results of Meta analysis showed that the overall effective rate of proton pump inhibitor combined with gastrointestinal motility drugs in the treatment of pharyngopharyngeal and laryngeal reflux was higher than that in the control group [RRN 1.1895 + CIQ 1.10 1.28 P 0.0001], and the improvement rate of laryngopharynx signs by fiberlaryngoscope was higher than that of the control group. In the control group, the average time for the disappearance of the symptoms of vocal disorders was shorter than that in the control group [RRN 1.38 / 95 CI 1.16 ~ 1.65] [MD-1.70 ~ 95CI-2.95 ~ (-0.45) P 0.001]. Conclusion Proton pump inhibitors combined with gastrointestinal motility drugs are more effective in the treatment of pharynx and larynx reflux than those of these two drugs alone, but more large samples and more multi-centers are needed in terms of safety. Methods A scientific, high-quality randomized controlled trial was used to further demonstrate.
【作者单位】：武汉大学人民医院耳鼻咽喉头颈外科;
【分类号】：R766

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