慢性中心性浆液性脉络膜视网膜病变半剂量光动力治疗前后脉络膜厚度的改变

发布时间：2018-06-16 10:26

本文选题：中心性浆液性脉络膜视网膜病变 + 脉络膜厚度　；参考：《武汉大学学报(医学版)》2014年04期

【摘要】：目的:应用频域光学相干断层扫描加强深度成像(EDI-OCT)技术定量分析慢性中心性浆液性脉络膜视网膜病变(CSC)患者光动力(PDT)治疗前后脉络膜厚度变化趋势。方法:在不散瞳条件下,使用CirrusTM HD OCT采用EDI技术,以长度6mm五线高清单线扫描模式对25例(37眼)进行后极部行水平及垂直方向扫描,获取黄斑区断层图像。定义视网膜色素上皮层外界至巩膜内界之间的垂直距离为脉络膜厚度。所有患者在PDT前,PDT治疗后半个月、1个月、3个月测量中心凹下及0°、90°、180°及270°处距离中心凹1.5mm处多位点脉络膜厚度,并分析PDT治疗前与治疗后半个月、治疗后半个月与治疗后1个月、治疗后1个月与治疗后3个月不同时间点脉络膜厚度的变化幅度。结果:所有患眼治疗前中心凹下脉络膜厚度为310-653μm,均值为(470.65±97.38)μm,术后半个月、1个月及3个月中心凹下脉络膜厚度均值分别为(435.81±76.47)μm、(351.68±85.08)μm、(310.81±66.85)μm,较治疗前均明显下降,具有显著的统计学意义;且光动力治疗后1月内脉络膜厚度减小幅度最大。0°、90°、180°及270°位点脉络膜厚度变化趋势与中心凹下脉络膜厚度变化趋势类似。结论:PDT治疗后,短期内慢性CSC患者脉络膜厚度呈下降趋势,且1个月内脉络膜厚度下降最为明显。
[Abstract]:Objective: to analyze the changes of choroidal thickness in patients with chronic central serous chorioretinopathy (CSCC) before and after treatment with frequency domain optical coherence tomography enhanced depth imaging (EDI-OCTT). Methods: under the condition of no pupil dilation, Cirrus TM HD Oct was used to perform horizontal and vertical scanning of posterior pole in 25 cases (37 eyes) with length 6mm five-line high-definition single line scan. The vertical distance from the outer part of the retinal pigment epithelium to the inner scleral boundary is defined as choroidal thickness. The choroidal thickness was measured half a month, one month and three months after the treatment. The choroidal thickness was measured at the point from the foveal 1.5mm at 0 掳, 90 掳, 180 掳and 270 掳, and was analyzed before and after the treatment, half a month after treatment and one month after treatment. The changes of choroidal thickness at different time points 1 month after treatment and 3 months after treatment. Results: the thickness of subcentral foveal choroid was 310-653 渭 m (mean 470.65 卤97.38) 渭 m before treatment, and the mean thickness of subcentral foveal choroid was 435.81 卤76.47 渭 m, 351.68 卤85.08 渭 m at half month, 1 month and 3 months after treatment, which was significantly lower than that before treatment. The change trend of choroidal thickness at 180 掳and 270 掳sites within 1 month after photodynamic therapy was similar to that of subcentral foveal choroid thickness. Conclusion the choroidal thickness of chronic CSC patients decreased in a short period after the treatment of 1: PDT, and the decrease was most obvious in one month.
【作者单位】：武汉大学人民医院眼科;
【分类号】：R773.4

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