Twist在鼻咽癌中的表达及意义的初步研究

发布时间：2018-06-23 23:42

本文选题：鼻咽癌 + Twist　；参考：《中南大学》2011年硕士论文

【摘要】：目的：探讨Twist在鼻咽癌中的表达情况及临床意义。研究方法：采用免疫组化法检测83例鼻咽癌和18例鼻咽部炎性组织中Twist的表达。对鼻咽癌组织中Twist的表达与临床病理因素及预后的关系进行统计学分析。结果：1、Twist在鼻咽部炎性组织中不表达,在鼻咽癌组织中的高表达率为49.4%,两者有显著的统计学差异(P=0.000)。 2、Twist表达与患者的年龄、性别及T分期无明显相关性(PO.05)。但是Twist高表达患者较低表达患者具有更高的淋巴结转移率(P0.001)、远处转移率(P=0.023)以及复发率P=0.040)。Twist的表达与淋巴结转移(r=0.414,P0.001)、远处转移(r=0.250,P=0.023)、复发存在正相关(r=0.226,P=0.04)。 3、Twist高表达组5年生存率为46.34%,Twist低表达组5年生存率为Twist74.42%,两组比较有显著统计学意义(P=0.007)。单因素分析显示鼻咽癌患者5年生存率与T分期、淋巴结转移情况、远处转移、TNM分期、Twist的表达水平相关(P0.05)。多因素分析显示淋巴结转移情况、远处转移、TNM分期及Twist的表达水平为鼻咽癌患者5年生存率的独立影响因素(P0.05)。结论：Twist在鼻咽部炎性组织中不表达,在鼻咽癌组织中有较高的阳性表达率。且与鼻咽癌的淋巴结转移、远处转移、以及复发密切相关。Twist可能作为判断鼻咽癌转移潜能和预后的辅助指标。
[Abstract]:Objective: to investigate the expression and clinical significance of Twist in nasopharyngeal carcinoma. Methods: the expression of Twist in 83 cases of nasopharyngeal carcinoma and 18 cases of nasopharyngeal inflammatory tissue was detected by immunohistochemical method. The relationship between Twist expression and clinicopathological factors and prognosis in nasopharyngeal carcinoma was analyzed statistically. Results there was no expression of Twist in nasopharyngeal inflammatory tissues, but a high expression rate of 49.4% in nasopharyngeal carcinoma (P < 0.000), but there was no significant correlation between the expression of Twist and age, sex and T stage (PO.05). But the patients with high expression of Twist had higher lymph node metastasis rate (P0.001), distant metastasis rate (P0. 023) and recurrence rate (P0. 040). The 5-year survival rate in Twist low expression group was Twist74.42, which was statistically significant (P0. 007). Univariate analysis showed that the 5-year survival rate was correlated with T stage, lymph node metastasis and the expression of Twist in TNM staging (P0.05). Multivariate analysis showed that lymph node metastasis, distant metastasis TNM stage and Twist expression level were independent factors of 5-year survival rate in nasopharyngeal carcinoma (P0.05). Conclusion Twist is not expressed in nasopharyngeal inflammatory tissue, but has a high positive rate in nasopharyngeal carcinoma. It was suggested that. Twist was closely related to lymph node metastasis, distant metastasis and recurrence of nasopharyngeal carcinoma (NPC), and might be an auxiliary index to judge metastasis potential and prognosis of nasopharyngeal carcinoma (NPC).
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R739.63

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