突发性聋与血脂代谢异常和血浆纤维蛋白原增高的相关性分析

发布时间：2018-06-26 00:53

本文选题：突发性聋 + 血脂代谢　；参考：《听力学及言语疾病杂志》2015年02期

【摘要】：目的分析突发性聋(sudden hearing loss,SHL)患者血脂代谢特点及血浆纤维蛋白原的水平,探讨其与突发性聋发病的相关性。方法 180例突发性聋患者(SHL组)根据纯音听阈曲线类型分为低中频下降组(低中频组)40例、高频下降组(高频组)90例、全频下降组(全频组)50例;另选取180例同期住院治疗、听力正常的鼻中隔偏曲、声带息肉患者作为对照组。检测各组对象的外周血甘油三脂(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、血糖(GLU)、血浆纤维蛋白原(FIB)的水平并行对比分析;对有意义的因素进行多因素Logistic回归分析。结果 SHL组(尤其是全频下降型和低中频下降型)TC、LDL-C、Glu、FIB高于对照组,HDL-C低于对照组,差异有统计学意义(P0.05),TG与对照组差异无统计学意义(P0.05);Logistic多因素分析显示LDL-C、FIB水平增高是突发性聋发病的主要相关危险因素。结论突发性聋患者血脂代谢异常,LDL-C和FIB水平增高是突发性聋发病的相关危险因素。
[Abstract]:Objective to analyze the metabolic characteristics of blood lipids and plasma fibrinogen levels in patients with sudden deafness (sudden hearing lossy) and to explore its correlation with the pathogenesis of sudden deafness. Methods 180 patients with sudden deafness (SHL group) were divided into four groups according to the type of pure tone threshold curve: low intermediate frequency descending group (low intermediate frequency group), high frequency descending group (high frequency group), and full frequency descending group (full frequency group), and 180 patients were hospitalized at the same time. Normal hearing nasal septum deviation, vocal cord polyp patients as the control group. The levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), blood glucose (GLU) and plasma fibrinogen (FIB) were measured in each group. Results the level of HDL-C in SHL group was higher than that in the control group, especially in the whole frequency and low intermediate frequency group, and the level of HDL-C in SHL group was lower than that in the control group. The difference was statistically significant (P0.05) there was no significant difference between TG and control group (P0.05). Logistic multivariate analysis showed that the increase of LDL-CfIB level was the main risk factor of sudden deafness. Conclusion the increased levels of LDL-C and FIB in patients with sudden deafness are related risk factors of sudden deafness.
【作者单位】：江苏省连云港市第一人民医院耳鼻咽喉头颈外科;连云港市第一人民医院医疗集团灌云县人民医院;
【基金】：连云港市卫生局立项基金(1001)资助
【分类号】：R764.437

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