频域相干光断层扫描定量分析视网膜大血管腔内直径与原发性高血压病相关性

发布时间：2018-06-29 10:47

本文选题：相干光断层扫描 + 视网膜血管　；参考：《浙江大学》2011年硕士论文

【摘要】：目的探讨通过频域相干光断层扫描(spectral domain optical coherence tomography, SD-OCT)对视网膜大血管“腔内”直径定量评价的意义,客观评估视网膜大血管“腔内”直径的变化与原发性高血压的相关性。方法病例对照研究。将自2009年以来,分别对为在我院就诊的原发性高血压病人群(215例)和正常血压人群(210例)按年龄的不同分组,通过SD-OCT对眼底视网膜大血管“腔内”直径的扫描检查,定量评估视网膜动脉“腔内”直径(retinal artery inner caliber, RAIC)、视网膜静脉的“腔内”直径(retinal vein inner caliber, RVIC)、以及动静脉“腔内”直径的比值(retinal arterio-venous inner caliber ratio, RAVICR),对比分析视网膜大血管“腔内”直径数据在高血压与正常人群之间的差异；在高血压人群内,按血压的不同分组进行多重比较,对比高血压发生后,RAIC和RAVICR随舒张压、收缩压变化的特点；并对高血压人群的RAVICR与舒张压、收缩压、年龄等相关因素进行多元逐步回归分析。结果在各年龄组内,高血压人群RAIC和RAVICR均较正常人群显著下降(P0.05,t检验)；在高血压人群中按血压不同分组多重比较,显示RAIC和RAVICR均随舒张压、收缩压的变化而出现相对的差异(P0.05,方差分析LSD检验)；多元线逐步回归分析显示高血压人群中,在a=0.05水平上,RAVICR与舒张压和收缩压2个因素有相关性,标准化后的回归系数(β)分别为-0.024、-0.019,模型方差分析(ANOVA)中的F=11.231,P=0.001,有统计学意义。结论借助SD-OCT可对视网膜大血管“腔内”直径进行对比分析；RAIC和RAVICR的变化与原发性高血压的舒张压和收缩压变化有相关性。
[Abstract]:Objective to investigate the significance of frequency domain coherence tomography (spectral domain optical coherence tomography, SD-Oct) in the quantitative evaluation of the "intracavity" diameter of retinal macrovascular, and to evaluate objectively the correlation between the change of "intracavity" diameter of retinal macrovascular and essential hypertension. Methods A case-control study was conducted. Since 2009, a group of 215 patients with essential hypertension (EH) and 210 patients with normal blood pressure (NBP) were divided into two groups according to age. The diameter of retinal vessels in the fundus was examined by SD-Oct. The retinal artery "intracavity" diameter (retinal artery inner caliber,), the retinal vein "intracavity" diameter (retinal vein inner caliber, Ric), and the ratio of arteriovenous "intracavity" diameter (retinal arterio-venous inner caliber ratio, RAVICR) were quantitatively evaluated. "differences in diameter data between hypertensive and normal populations; In the hypertensive population, the changes of RAIC and RAVICR with diastolic blood pressure and systolic blood pressure were compared according to different groups of blood pressure, and the changes of RAVICR and diastolic blood pressure and systolic blood pressure were compared. Multiple stepwise regression analysis was carried out for age and other related factors. Results in all age groups, the Raic and RAVICR in hypertensive population were significantly lower than those in normal subjects (P0.05t test), and the results showed that Raic and RAVICR were both with diastolic blood pressure (DBP). There were relative differences in systolic blood pressure (P0.05, ANOVA LSD test), multiple linear stepwise regression analysis showed that RAVICR was correlated with diastolic blood pressure and systolic blood pressure at a0.05 level. The standardized regression coefficients (尾) were -0.024 ~ 0.019, respectively, and the model variance analysis (ANOVA) showed a significant difference in the analysis of variance (ANOVA). Conclusion SD-Oct can be used to compare the "intracavity" diameters of large retinal vessels and to analyze the correlation between the changes of RAIC and RAVICR and the changes of diastolic and systolic blood pressure in essential hypertension.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R774.1

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