共同性斜视患者大脑皮层激活强度的功能磁共振研究

发布时间：2018-07-04 09:58

本文选题：共同性斜视 + 大脑皮层　；参考：《眼科新进展》2015年03期

【摘要】：目的采用血氧水平依赖性功能磁共振成像(blood oxygen level dependent functional magnetic resonance imaging,BOLD-fMRI)技术比较共同性斜视患者与正常受试者在接受不同视差的立体图刺激下激活脑区和激活强度的差异。方法选取共同性斜视患者12例,立体视觉正常者10例,进行组块设计的fMRI研究。采用SPM5对数据进行预处理及分析。结果两组激活强度比较差异有统计学意义(P0.05)。在视差1200″刺激下,共同性斜视组激活强度低于正常组的区域表现为双侧枕中回(BA18)、双侧额下回(BA45/47)、右侧颞下回(BA37)、左侧顶下小叶(BA40)、左侧中央后回(BA2)、左侧岛叶(BA13)。在视差2400″刺激下,共同性斜视组激活强度低于正常组的区域表现为双侧枕中回(BA18)、右侧颞下回(BA37)、双侧海马(BA28)、左侧颞上回(BA20);共同性斜视组激活强度高于正常组的区域表现为右侧舌回(BA18)。在视差3600″刺激下,共同性斜视组激活强度低于正常组的区域表现为右侧额下回(BA47)、左侧枕中回(BA18)、右侧枕下回(BA18)、左侧岛叶(BA13);共同性斜视组激活强度高于正常组的区域表现为右侧额中回(BA8/10)。结论共同性斜视患者右侧舌回、额中回的激活强度高于正常人,双侧枕叶、颞叶、额叶及左侧岛叶、顶叶的激活强度均低于正常人。
[Abstract]:Objective to compare the difference of activation intensity between concomitant strabismus patients and normal subjects under different parallax stereoscopic stimuli by using (blood oxygen level dependent functional magnetic resonance imaging and BOLD-fMRI techniques in blood oxygen level dependent functional magnetic resonance imaging (fMRI). Methods 12 cases of concomitant strabismus and 10 cases of normal stereopsis were studied by fMRI. SPM 5 was used to preprocess and analyze the data. Results there was significant difference in activation intensity between the two groups (P0.05). Under the stimulation of 1200 "parallax, the activation intensity of concomitant strabismus group was lower than that of normal group: bilateral middle occipital gyrus (BA18), bilateral inferior frontal gyrus (BA45 / 47), right infratemporal gyrus (BA37), left subparietal lobe (BA40), left posterior central gyrus (BA2), left insular lobe (BA13). Stimulated by parallax of 2400 ", In concomitant strabismus group, the activation intensity of bilateral occipital middle gyrus (BA18), right infratemporal gyrus (BA37), bilateral hippocampus (BA28), left superior temporal gyrus (BA20) was lower than that of normal group, and that of concomitant strabismus group was higher than that of normal group (BA18). Stimulated by parallax of 3600 ", In concomitant strabismus group, the activation intensity of right inferior frontal gyrus (BA47), left middle occipital gyrus (BA18), right inferior occipital gyrus (BA18) and left insular lobe (BA13) were lower than those of normal group, and that of concomitant strabismus group was higher than that of normal group (BA8 / 10). Conclusion the activation intensity of right lingual gyrus and middle frontal gyrus in concomitant strabismus is higher than that in normal subjects. The activation intensity of bilateral occipital lobe, temporal lobe, frontal lobe, left insular lobe and parietal lobe is lower than that of normal subjects.
【作者单位】：成都医学院第一附属医院眼科;海口市人民医院;中南大学湘雅医学院附属海口医院眼科;中南大学湘雅医学院附属海口医院放射科;
【基金】：海南省自然科学基金项目(编号:811154) 海口市重点科技计划项目(编号:2010-170)~~
【分类号】：R445.2;R777.41

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