阻塞性睡眠呼吸暂停低通气综合征患者呼出气冷凝液中内皮素-1水平及临床意义研究

发布时间：2018-07-05 11:08

本文选题：睡眠呼吸暂停 + 阻塞性　；参考：《中国全科医学》2014年29期

【摘要】：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者呼出气冷凝液(EBC)中内皮素-1(ET-1)水平与疾病严重程度关系。方法选择2011年9月—2013年6月广东医学院附属南山医院呼吸科因打鼾就诊患者中非吸烟OSAHS患者59例(其中轻、中、重度患者分别为23、19、17例),另选择同期性别、年龄与OSAHS患者匹配的23例健康非吸烟者作为对照组。使用EBC收集仪器采集入组时睡前、晨起醒后EBC,采用酶联免疫吸附试验(ELISA)法测定ET-1水平;ET-1与疾病严重程度〔颈围、睡眠呼吸暂停低通气指数(AHI)、睡眠中最低血氧饱和度(SaO2)〕的关系采用Pearson相关分析。结果对照组晨起ET-1水平〔(5.0±0.4)pg/ml〕与睡前〔(5.1±0.5)pg/ml〕比较,差异无统计学意义(P0.05);OSAHS轻、中、重度组晨起ET-1水平均较睡前增高,差异有统计学意义(P0.05)。各组睡前ET-1水平间差异无统计学意义(P0.05),各组晨起ET-1水平两两比较差异均有统计学意义(P0.05)。OSAHS患者晨起ET-1水平与颈围、AHI呈正相关(r=0.637、0.920,P0.05),与睡眠中最低SaO2呈负相关(r=-0.814,P0.05)。结论 EBC中ET-1水平与OSAHS患者疾病严重程度相关,病情越重,晨起ET-1水平越高;晨起EBC中ET-1水平可作为评估OSAHS严重程度的有效指标之一。
[Abstract]:Objective to investigate the relationship between the level of endothelin-1 (ET-1) and the severity of the disease in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods from September 2011 to June 2013, 59 patients with non-smoking OSAHS were selected from Department of Respiratory Department, Nanshan Hospital affiliated to Guangdong Medical College. Age matched OSAHS patients with 23 healthy non-smokers as control group. EBC was collected by EBC collecting instrument before bedtime and waking up in the morning. The level of ET-1 and the severity of disease (neck circumference) were measured by enzyme-linked immunosorbent assay (Elisa). The relationship between sleep apnea hypopnea index (AHI) and minimum oxygen saturation (SaO2) in sleep was analyzed by Pearson correlation. Results the level of ET-1 in the control group (5.0 卤0.4) pg/ml) was significantly higher than that in the control group (5.1 卤0.5) pg/ml) (P0.05). The level of ET-1 in the moderate and severe group was significantly higher than that in the control group (P0.05). There was no significant difference in ET-1 level between groups before bedtime (P0.05). There were significant differences in ET-1 level between groups from morning to morning (P0.05). There was a positive correlation between ET-1 level and neck circumference AHI in OSAHS patients (r = 0.6370.9020), and a negative correlation between ET-1 level and lowest SaO2 in sleep (r-0.814P0.05). Conclusion the level of ET-1 in EBC is correlated with the severity of OSAHS. The more serious the disease, the higher the level of ET-1 in the morning, and the level of ET-1 in EBC can be used as an effective index to evaluate the severity of OSAHS.
【作者单位】：广东医学院附属南山医院呼吸内科;
【分类号】：R766

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