糖尿病性视网膜病变激光光凝面积百分比与激光治疗效果分析

发布时间：2018-07-10 17:48

本文选题：糖尿病性视网膜病变 + 激光光凝　；参考：《吉林大学》2011年硕士论文

【摘要】：目的: 糖尿病眼部最常见的并发症是糖尿病性视网膜病变(diabetic retinopathy,DR),是主要的致盲眼病之一。视网膜光凝是治疗糖尿病性视网膜病变的有效手段。本实验旨在通过计算机软件量化激光斑面积,计算全视网膜光凝后激光斑所占视网膜面积百分比,探讨激光斑面积与视力及黄斑厚度容积之间的关系。方法: 选择糖尿病性视网膜病变4期患者30例共60只眼,行视网膜激光光凝治疗。将其分成无黄斑水肿(48只眼)和黄斑水肿(12只眼)两大类别,将无黄斑水肿患者随机分成A组(间隔一个激光斑)和B组(间隔两个激光斑),每组24只眼。将黄斑水肿患者随机分成C组(间隔一个激光斑)和D组(间隔两个激光斑),每组6只眼。A、B组行全视网膜光凝, C、D组先行黄斑格栅样光凝,1周后再行全视网膜光凝,4组均在术前及术后3个月观察视力及用OCT测量黄斑厚度容积的变化。根据图像分割和canny边界识别理论,运用Matlab2010b开发环境设计计算机软件plotArea (与吉林大学计算机科学与技术学院合作开发),分析测量A、B、C、D四组眼底激光斑面积占眼底图总面积的百分比,比较激光斑面积比值与激光治疗效果的关系。结果: 1.术后眼底激光斑间隔一个激光斑距离,激光斑面积(像素) 20000-50000,百分比为25%-40%;激光斑间隔两个激光斑距离,激光斑面积(像素) 10000-20000,百分比为10%-25%。 2. A组B组术前视力黄斑厚度容积比较无明显差异性,P0.05,C组D组术前视力黄斑厚度容积比较无明显差异性,P0.05。A组与B组术后视力无显著差异,P0.05;C组D组术后的视力有显著差异,P0.05;A组B组术后黄斑厚度及容积无显著差异,P0.05;C组D组术后黄斑厚度及容积有显著差异, P0.05。结论: 全视网膜光凝间隔一个激光斑,激光斑所占视网膜面积在25%-40%范围内。间隔两个激光斑,激光斑所占视网膜面积在10%-25%范围内。对于黄斑水肿组,激光斑所占视网膜面积在25%-40%范围内,术后视力及黄斑厚度容积恢复较好。
[Abstract]:Objective: the most common complication of diabetic eyes is diabetic retinopathy Dr. Retinal photocoagulation is an effective method for the treatment of diabetic retinopathy. The purpose of this experiment was to quantify the laser spot area by computer software and to calculate the percentage of the laser spot area in the retina after total retinal photocoagulation, and to explore the relationship between the laser spot area and the visual acuity and macular thickness volume. Methods: 30 cases (60 eyes) of stage 4 diabetic retinopathy were treated by laser photocoagulation. They were divided into two groups: no macular edema (48 eyes) and macular edema (12 eyes). Patients without macular edema were randomly divided into two groups: group A (one laser spot spacer) and group B (two laser spots spacer) with 24 eyes in each group. The patients with macular edema were randomly divided into two groups: group C (one laser spot spacer) and group D (two laser spots spacer). Each group (6 eyes) was treated with total retinal photocoagulation. Group C (C) D was treated with macular grid photocoagulation for 1 week and then with total retinal light. The visual acuity and macular thickness volume were measured by Oct before and 3 months after operation. According to the theory of image segmentation and canny boundary recognition, using Matlab 2010b to design the computer software plotArea (developed in cooperation with the School of computer Science and Technology, Jilin University), the percentage of laser spot area in the total area of the fundus image in the four groups of Agna Bu C D was analyzed and measured. To compare the relation between laser spot area ratio and laser therapeutic effect. Results: 1. One laser spot distance, laser spot area (pixel) 20000-50000, percent 25-40, laser spot distance, laser spot area (pixel) 10000-20000, percent 10-25.2. There was no significant difference in preoperative macular thickness volume between group B and group B; there was no significant difference in preoperative volume of macular thickness between group D and group D; there was no significant difference between group P0.05.A and group B; there was no significant difference in visual acuity between group D and group D; there was no significant difference in postoperative visual acuity between group D and group B; There was no significant difference in macular thickness and volume between group B and group B. There was significant difference in thickness and volume of macular in group D (P 0.05) and group D (P 0.05). Conclusion: the total retinal photocoagulation interval is a laser spot, and the area of the retina is between 25% and 40%. Between two laser spots, the retina area occupied by laser spot was in the range of 10-25%. For macular edema group, the retinal area occupied by laser spot ranged from 25% to 40%, and the visual acuity and macular thickness volume recovered better.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R774.1

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